Publications de Simon Borgognon

Regional specialization of movement encoding across the primate sensorimotor cortex

Grégoire Courtine, Jocelyne Bloch, Tomislav Milekovic, Simon Borgognon, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

Loss of Motor Cortical Inputs to the Red Nucleus after CNS Disorders in Nonhuman Primates

Simon Borgognon

The premotor (PM) and primary motor (M1) cortical areas broadcast voluntary motor commands through multiple neuronal pathways, including the corticorubral projection that reaches the red nucleus (RN). However, the respective contribution of M1 and PM to co ...

SOC NEUROSCIENCE2023

A spinal cord neuroprosthesis for locomotor deficits due to Parkinson's disease

Auke Ijspeert, Silvestro Micera, Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Jordan Squair, Giuseppe Schiavone, Léonie Asboth, Tomislav Milekovic

People with late-stage Parkinson's disease (PD) often suffer from debilitating locomotor deficits that are resistant to currently available therapies. To alleviate these deficits, we developed a neuroprosthesis operating in closed loop that targets the dor ...

Nature Portfolio2023

Bayesian optimization of peripheral intraneural stimulation protocols to evoke distal limb movements

Silvestro Micera, Grégoire Courtine, Simon Borgognon, Sophie Marie Marthe Wurth, Marion Aimée Geneviève Badi-Dubois

Objective. Motor neuroprostheses require the identification of stimulation protocols that effectively produce desired movements. Manual search for these protocols can be very time-consuming and often leads to suboptimal solutions, as several stimulation pa ...

IOP Publishing Ltd2021

Recruitment of upper-limb motoneurons with epidural electrical stimulation of the cervical spinal cord

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Nicholas David James, Simon Borgognon, Henri Charles Alexandre Lorach, Florian Dylan Fallegger, Nathan Antoine Greiner

Epidural electrical stimulation (EES) of lumbosacral sensorimotor circuits improves leg motor control in animals and humans with spinal cord injury (SCI). Upper-limb motor control involves similar circuits, located in the cervical spinal cord, suggesting t ...

Nature Research2021

Intrafascicular peripheral nerve stimulation produces fine functional hand movements in primates

Silvestro Micera, Grégoire Courtine, Simon Borgognon, Evgenia Vladimirova Roussinova, Sophie Marie Marthe Wurth, Marion Aimée Geneviève Badi-Dubois

Restoring dexterous hand control is critical for people with paralysis. Approaches based on surface or intramuscular stimulation provide limited finger control, generate insufficient force to recover functional movements, and require numerous electrodes. H ...

AMER ASSOC ADVANCEMENT SCIENCE2021

Soft, Implantable Bioelectronic Interfaces for Translational Research

Stéphanie Lacour, Grégoire Courtine, Giuseppe Schiavone, Jocelyne Bloch, Ismael Seanez Gonzalez, Sébastien Jiguet, Ivan Furfaro, Simon Borgognon, Evgenia Vladimirova Roussinova, Marco Capogrosso

The convergence of materials science, electronics, and biology, namely bioelectronic interfaces, leads novel and precise communication with biological tissue, particularly with the nervous system. However, the translation of lab‐based innovation toward cli ...

Wiley2020

Cortical Projection From the Premotor or Primary Motor Cortex to the Subthalamic Nucleus in Intact and Parkinsonian Adult Macaque Monkeys: A Pilot Tracing Study

Simon Borgognon, Jocelyne Bloch, Simon Pierre Jean Badoud

Besides the main cortical inputs to the basal ganglia, via the corticostriatal projection, there is another input via the corticosubthalamic projection (CSTP), terminating in the subthalamic nucleus (STN). The present study investigated and compared the CS ...

FRONTIERS MEDIA SA2020