Personne
Linlin Cao
Cette personne n’est plus à l’EPFL
Publications associées (5)
Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...
EPFL2023A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes
The activation of memory T cells is a very rapid and concerted cellular response that requires coordination between cellular processes in different compartments and on different time scales. In this study, we use ribosome profiling and deep RNA sequencing ...
AMER ASSOC IMMUNOLOGISTS2022NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy
Inhibition of the eIF4A RNA helicase with silvestrol and related compounds is emerging as a powerful anti-cancer strategy. We find that a synthetic silvestrol analogue (CR-1-31 B) has nanomolar activity across many cancer cell lines. It is especially activ ...
2021Pharmacological disruption of the Notch transcription factor complex
Freddy Radtke, Ute Koch, Nadine Fournier, Jelena Zaric, Rajwinder Lehal, Linlin Cao, Michele Vigolo
Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...
NATL ACAD SCIENCES2020Computational Fluid Dynamics-Based Pump Redesign to Improve Efficiency and Decrease Unsteady Radial Forces
Linlin Cao, Ning Chu, Shuai Yang, Peng Wu
In this study, a double volute centrifugal pump with relative low efficiency and high vibration is redesigned to improve the efficiency and reduce the unsteady radial forces with the aid of unsteady computational fluid dynamics (CFD) analysis. The concept ...
Asme2017