Publications de Lixia Wei | EPFL Graph Search

Cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Francesco Stellacci, Quy Ong Khac, Lixia Wei

A method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject includes: (a) determining the protein level of at least one protein in the sample of isolated cholesterol-rich lipoprotein nanoparti ...

2025

Efficient Direct Cytosolic Protein Delivery via Protein-Linker Co-engineering

Francesco Stellacci, Heyun Wang, Lixia Wei, Suiyang Liao

Protein therapeutics have enormous potential for transforming the treatment of intracellular cell disorders, such as genetic disorders and cancers. Due to proteins’ cell-membrane impermeability, protein-based drugs against intracellular targets require eff ...

American Chemical Society (ACS)2025

Size distributions and fractograms of cholesterol-rich lipoprotein nanoparticles for cancer diagnosis

Francesco Stellacci, Quy Ong Khac, Lixia Wei

The present invention relates to a method for the diagnosis of cancer in a sample of cholesterol-rich lipoprotein nanoparticles obtained from a test subject comprising (α) determining the size distribution or the fractogram in chromatography of the cholest ...

2025

Benzene with Alkyl Chains Is a Universal Scaffold for Multivalent Virucidal Antivirals

Francesco Stellacci, Heyun Wang, Paulo Henrique Jacob Silva, Matteo Gasbarri, Lixia Wei, Yong Zhu

Most viruses start their invasion by binding to glycoproteins' moieties on the cell surface (heparan sulfate proteoglycans [HSPG] or sialic acid [SA]). Antivirals mimicking these moieties multivalently are known as broad-spectrum multivalent entry inhibito ...

Amer Chemical Soc2024

A Synthetic Multivalent Lipopeptide Derived from Pam3CSK4 with Irreversible Influenza Inhibition and Immuno-Stimulating Effects

Francesco Stellacci, Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Quy Ong Khac, Francesca Olgiati, Pablo Gainza Cirauqui, Lixia Wei, Armand Kurum, Yong Zhu

The activation of the host adaptive immune system is crucial for eliminating viruses. However, influenza infection often suppresses the innate immune response that precedes adaptive immunity, and the adaptive immune responses are typically delayed. Dendrit ...

Wiley-V C H Verlag Gmbh2024

Influence of structural dynamics on cell uptake investigated with single-chain polymeric nanoparticles

Francesco Stellacci, Arthur Eliot Bouchez, Lixia Wei, Suiyang Liao

Most nanoparticles' parameters affect their interactions with cells. To date, all the parameters studied are basically static (e.g., size, shape, ligands, and charge). This is unfortunate, because proteins have struc-tural dynamics that most nanoparticles ...

CELL PRESS2023

Protein Engineering for Personalized therapy and diagnosis

Lixia Wei

Protein Engineering, especially protein post-translational modification (PTM), ex-tends proteomes in a more complex way than one can expect from analysis of their encod-ing genomes. It can activate or deactivate certain catalytic functions, add new desired ...

EPFL2022

Peptide-Grafted Nontoxic Cyclodextrins and Nanoparticles against Bacteriophage Infections

Francesco Stellacci, Paulo Henrique Jacob Silva, Lixia Wei, Corey Alfred Stevens, Lukasz Richter

One of the biggest threats for bacteria-based bioreactors in the biotechnology industry is infections caused by bacterial viruses called bacteriophages. More than 70% of companies admitted to encountering this problem. Despite phage infections being such a ...

AMER CHEMICAL SOC2022

Structural Evolution Of Knowledge Network And Behavior Variation Of Knowledge Subject Driven By Emotional Behavior

Lixia Wei

OXFORD UNIV PRESS2022

Analysis of the mechanism of renewable energy on energy-saving and environmental protection industry: Empirical evidence from four countries

Lixia Wei

The "Carbon Peaking and Carbon Neutrality" strategy of China has accelerated the process of industrial structure transformation of global energy-saving and environmental protection. With the international efforts to cope with climate change and the growing ...

ELSEVIER2022