Publications de Jocelyne Bloch

Online prediction of optimal deep brain stimulation contacts from local field potentials in Parkinson’s disease

Selecting optimal contacts for chronic deep-brain stimulation (DBS) requires a monopolar review, involving time-consuming manual testing by trained personnel, often causing patient discomfort. Neural biomarkers, such as local field potentials (LFP), could ...

2025

A clinical road map for single-cell omics

Grégoire Courtine, Jocelyne Bloch

In a matter of years, single-cell omics has matured from a pioneering technique employed by just a handful of specialized laboratories to become a ubiquitous feature of biological research and a key driver of scientific discovery. The widespread adoption a ...

2025

Augmenting rehabilitation robotics with spinal cord neuromodulation: A proof of concept

Auke Ijspeert, Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Robin Jonathan Demesmaeker, Miroslav Caban, Nicolas Hankov, Henri Charles Alexandre Lorach, Fabien Bertrand Paul Wagner, Salif Axel Komi

Rehabilitation robotics aims to promote activity-dependent reorganization of the nervous system. However, people with paralysis cannot generate sufficient activity during robot-assisted rehabilitation and, consequently, do not benefit from these therapies. ...

AMER ASSOC ADVANCEMENT SCIENCE2025

Regional specialization of movement encoding across the primate sensorimotor cortex

Grégoire Courtine, Jocelyne Bloch, Tomislav Milekovic, Simon Borgognon, Ismael Seanez Gonzalez, Nicolò Macellari

The process by which the cerebral cortex generates movements to achieve different tasks remains poorly understood. Here, we leveraged the rich repertoire of well-controlled primate locomotor behaviors to study how task-specific movements are encoded across ...

Springer Science and Business Media LLC2025

High-resolution prosthetic hearing with a soft auditory brainstem implant in macaques

Stéphanie Lacour, Jocelyne Bloch, Ivan Furfaro, Florent-Valéry Coen, Alix Esther Anne Trouillet, Emilie Cornelia Maria Revol, Laurine Kolly, Florian Dylan Fallegger

Individuals with compromised cochlear nerves are ineligible for cochlear implants and instead rely on auditory brainstem implants (ABIs). Most users of ABIs experience sound awareness, which aids in lip reading, yet not speech intelligibility. Here we engi ...

2025

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Nicholas David James, Matthieu Pierre Gautier, Claudia Kathe, Thomas Haynes Hutson, Michael Alexander Skinnider, Michael V. Sofroniew

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

System for control of spasticity

Grégoire Courtine, Jocelyne Bloch, Robin Jonathan Demesmaeker, Fabien Bertrand Paul Wagner, Karen Minassian, Salif Axel Komi

The present invention relates to a neuromodulation/neurostimulation system (10) for the treatment of spasticity in a mammal, said system (10) comprising: - at least one control unit (12) configured and arranged to provide stimulation data, and - at least o ...

2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier, Nicolas Hankov

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Lateral medullary vascular compression manifesting as paroxysmal hypertension

Jocelyne Bloch

Neurovascular compression of the rostral ventrolateral medulla (RVLM) has been described as a possible cause of refractory essential hypertension. We present the case of a patient affected by episodes of severe paroxysmal hypertension, some episodes associ ...

2024

Neuromodulation/neurostimulation system for controlling a respiratory function

Grégoire Courtine, Jocelyne Bloch, Léonie Asboth, Vincent Delattre, Robin Jonathan Demesmaeker, Miroslav Caban, Nicolas Hankov

The present invention relates to a neuromodulation/neurostimulation system for supporting and/or controlling a function of t he respiratory system of a patient, said function comprising a plurality of phases each involving one or more muscles. The system c ...

2024