Publications de Csaba Ferenc László

Mimicking women’s endocrine milieu in mice for women’s health-related studies

Cathrin Brisken, Laura Battista, Valentina Scabia, Céline Berthe Constantin, Csaba Ferenc László

To improve preclinical studies and their translation, patient-derived xenografts (PDXs) are increasingly used. They have human-specific tumor characteristics and reflect intra and inter-tumor heterogeneity. However, the endocrine milieu differs between hum ...

Springer Science and Business Media LLC2025

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Cathrin Brisken, Giovanna Ambrosini, Ayyakkannu Ayyanan, Laura Battista, Valentina Scabia, Fabio De Martino, Csaba Ferenc László, Andrea Agnoletto

Estrogen and progesterone receptor (ER, PR) signaling control breast development and impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target gene, is debated. We assess the issue in clinical ...

Nature Portfolio2022

Contraceptive progestins with androgenic properties stimulate breast epithelial cell proliferation

Cathrin Brisken, Giovanna Ambrosini, Laura Battista, Philipp Bucher, Valentina Scabia, Fabio De Martino, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László

Hormonal contraception exposes women to synthetic progesterone receptor (PR) agonists, progestins, and transiently increases breast cancer risk. How progesterone and progestins affect the breast epithelium is poorly understood because we lack adequate mode ...

2021

The secreted protease Adamts18 links hormone action to activation of the mammary stem cell niche

Cathrin Brisken, Giovanna Ambrosini, Marian Caikovski, Dalya Ataca, Philipp Bucher, Renuga Devi Rajaram, Patrik Aouad, Marie Shamseddin, Céline Berthe Constantin, Csaba Ferenc László

Estrogens and progesterone control breast development and carcinogenesis via their cognate receptors expressed in a subset of luminal cells in the mammary epithelium. How they control the extracellular matrix, important to breast physiology and tumorigenes ...

Nature Research2020

A high resolution LC-MS targeted method for the concomitant analysis of 11 contraceptive progestins and 4 steroids

Cathrin Brisken, Marc Moniatte, Fabio De Martino, Jonathan Paz Montoya, Marie Shamseddin, Csaba Ferenc László, Alexandre Béguin

In the context of hormonal contraception and hormone replacement therapy (HRT), many women are exposed to exogenous hormones. Current use of hormonal contraception with combined ethinyl estradiol and different progestins bestows a breast cancer relative ri ...

2019

Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation

Cathrin Brisken, Melody Swartz, Witold Waldemar Kilarski, Csaba Ferenc László, Elena Menietti, Dania Al Labban

Stromal fibroblast senescence has been linked to ageing-associated cancer risk. However, density and proliferation of cancer-associated fibroblasts (CAFs) are frequently increased. Loss or downmodulation of the Notch effector CSL (also known as RBP-Jκ) in ...

Nature Publishing Group2015