Publications de Claudia Kathe | EPFL Graph Search

Single-cell and spatial atlases of spinal cord injury in the Tabulae Paralytica

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Nicholas David James, Matthieu Pierre Gautier, Claudia Kathe, Thomas Haynes Hutson, Michael Alexander Skinnider, Michael V. Sofroniew

Here, we introduce the Tabulae Paralytica—a compilation of four atlases of spinal cord injury (SCI) comprising a single-nucleus transcriptome atlas of half a million cells, a multiome atlas pairing transcriptomic and epigenomic measurements within the same ...

Springer Science and Business Media LLC2024

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Léonie Asboth, Mark Andrew Anderson, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier, Nicolas Hankov

A spinal cord injury (SCI) disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking, leading to various degrees of paralysis. Here, we aimed to identify brain regions that steer the recovery of walking after i ...

NATURE PORTFOLIO2024

Magnesium Test: Universal and Ultra-Sensitive Method for Measuring Reliability of Thin-Film-Encapsulated Bioelectronic Implants in Physiological Environment

Yves Leterrier, Stéphanie Lacour, Grégoire Courtine, Ivan Furfaro, Kangling Wu, Lei Wang, Claudia Kathe, Massimo Mariello

Next-generation bioelectronic implants require miniaturization, durability, and long-term functionality. Thin film encapsulations, prepared with inorganic or hybrid organic/inorganic designs, are essential for ensuring protection, low water permeation, ada ...

Wiley-V C H Verlag Gmbh2024

Recovery of walking after paralysis by regenerating characterized neurons to their natural target region

Grégoire Courtine, Bernard Schneider, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Katia Galan, Nicholas David James, Matthieu Pierre Gautier, Laetitia Danielle Philippine Baud

Axon regeneration can be induced across anatomically complete spinal cord injury (SCI), but robust functional restoration has been elusive. Whether restoring neurological functions requires directed regeneration of axons from specific neuronal subpopulatio ...

American Association for the Advancement of Science2023

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Ileana Ozana Jelescu, Ivan Furfaro, Kyungjin Kim, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Claudia Kathe

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Single cell atlas of spinal cord injury in mice reveals a pro-regenerative signature in spinocerebellar neurons

Grégoire Courtine, Claudia Kathe, Jordan Squair, Yi Ding

After spinal cord injury, tissue distal to the lesion contains undamaged cells that could support or augment recovery. Targeting these cells requires a clearer understanding of their injury responses and capacity for repair. Here, we use single nucleus RNA ...

Nature Portfolio2022

The neurons that restore walking after paralysis

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Quentin Barraud, Jordan Squair, Léonie Asboth, Katia Galan, Robin Jonathan Demesmaeker, Nicholas David James, Matthieu Pierre Gautier

A spinal cord injury interrupts pathways from the brain and brainstem that project to the lumbar spinal cord, leading to paralysis. Here we show that spatiotemporal epidural electrical stimulation (EES) of the lumbar spinal cord(1-3) applied during neurore ...

NATURE PORTFOLIO2022

Natural and targeted circuit reorganization after spinal cord injury

Grégoire Courtine, Quentin Barraud, Jocelyne Bloch, Matthieu Pierre Gautier, Claudia Kathe, Jordan Squair, Mark Andrew Anderson, Thomas Haynes Hutson

The authors summarize changes in circuits after spinal cord injury and current strategies to target these circuits in order to improve recovery, but also advocate for new concepts of reorganizing circuits informed by multi-omic single-cell atlases. ...

NATURE PORTFOLIO2022

Confronting false discoveries in single-cell differential expression

Grégoire Courtine, Gioele La Manno, Quentin Barraud, Jordan Squair, Mark Andrew Anderson, Nicholas David James, Matthieu Pierre Gautier, Thomas Haynes Hutson, Rémi Bernard René Hudelle, Claudia Kathe

Differential expression analysis of single-cell transcriptomics allows scientists to dissect cell-type-specific responses to biological perturbations. Here, the authors show that many commonly used methods are biased and can produce false discoveries. ...

Nature Portfolio2021

Neuroprosthetic baroreflex controls haemodynamics after spinal cord injury

Stéphanie Lacour, Grégoire Courtine, Jocelyne Bloch, Eduardo Martin Moraud, Quentin Barraud, Jordan Squair, Giuseppe Schiavone, Ileana Ozana Jelescu, Mark Andrew Anderson, Robin Jonathan Demesmaeker

Spinal cord injury (SCI) induces haemodynamic instability that threatens survival(1-3), impairs neurological recovery(4,5), increases the risk of cardiovascular disease(6,7), and reduces quality of life(8,9). Haemodynamic instability in this context is due ...

NATURE RESEARCH2021