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Organoids are powerful models for studying tissue development, physiology, and disease. However, current culture systems disrupt the inductive tissue-tissue interactions needed for the complex morphogenetic processes of native organogenesis. Here, we show ...
CELL PRESS2021
Macrophages (MPs) are immune cells which are crucial for tissue repair. In skeletal muscle regeneration, pro-inflammatory cells first infiltrate to promote myogenic cell proliferation, then they switch into an anti-inflammatory phenotype to sustain myogeni ...
Tissue and organ biology are very challenging to study in mammals, and progress can be hindered, particularly in humans, by sample accessibility and ethical concerns. However, advances in stem cell culture have made it possible to derive in vitro 3D tissue ...
Polarised three-dimensional cellular aggregates (or gastruloids) generated in vitro from one or more pluripotent stem cells are provided. Methods for obtaining polarised three-dimensional cellular aggregates and cells (e.g. progenitor cells and derivatives ...
