Publications de Sailan Shui | EPFL Graph Search

Dual ON/OFF-switch chimeric antigen receptor controlled by two clinically approved drugs

Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Leo Scheller, Sailan Shui

The ability to remotely control the activity of chimeric antigen receptors (CARs) with small molecules can improve the safety and efficacy of gene-modified T cells. Split ON- or OFF-switch CARs involve the dissociation of tumor–antigen binding from T cell ...

National Academy of Sciences2024

Rational Design of Chemically Controlled Antibodies and Protein Therapeutics

Li Tang, Bruno Emanuel Ferreira De Sousa Correia, Sandrine Madeleine Suzanne Georgeon, Anthony Marchand, Leo Scheller, Lucia Bonati, Pablo Gainza Cirauqui, Stéphane Rosset, Sailan Shui

Protein-based therapeutics, such as monoclonal antibodies and cytokines, are important therapies for various pathophysiological conditions such as oncology, autoimmune disorders, and viral infections. However, the wide application of such protein therapeut ...

2023

Rational design of small-molecule responsive protein switches

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Stephen Michael Buckley, Sailan Shui

Small-molecule responsive protein switches are powerful tools for controlling cellular processes. These switches are designed to respond rapidly and specifically to their inducer. They have been used in numerous applications, including the regulation of ge ...

2023

Protein-based bandpass filters for controlling cellular signaling with chemical inputs

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Sailan Shui

Biological signal processing is vital for cellular function. Similar to electronic circuits, cells process signals via integrated mechanisms. In electronics, bandpass filters transmit frequencies with defined ranges, but protein-based counterparts for cont ...

Nature Portfolio2023

Rational design of protein switches: applications in synthetic biology and cancer immunotherapy

Sailan Shui

Synthetic biology aims to engineer cells as miniature biological devices to sense, process, and respond to exogenous stimuli. Protein switches are designed to sense and respond to various molecular queues in a fast and specific manner, which fits the requi ...

EPFL2022

Novel chemically controlled cellular switches

Bruno Emanuel Ferreira De Sousa Correia, Pablo Gainza Cirauqui, Sailan Shui

The invention relates to activation by inhibitor release (AIR) switches and chemically disruptable heterodimers (CDH), their use in controlling cell signaling components, and their use for treatments and therapies. ...

2022

Computational design of bioactive protein switches with multi-logics for cell-based therapeutics

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Pablo Gainza Cirauqui, Che Yang, Sailan Shui

WILEY2021

A computationally designed chimeric antigen receptor provides a small-molecule safety switch for T-cell therapy

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Jaume Bonet Martinez, Pablo Gainza Cirauqui, Sabrina Susan Vollers, Sailan Shui

The activity of CAR-T cells is reversibly halted with a small-molecule drug. Approaches to increase the activity of chimeric antigen receptor (CAR)-T cells against solid tumors may also increase the risk of toxicity and other side effects. To improve the s ...

2020

OFF-switch CAR T cell for safety-enhanced cancer immunotherapy

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Pablo Gainza Cirauqui, Sabrina Susan Vollers, Sailan Shui

AMER ASSOC CANCER RESEARCH2018