Publications de Philipp Johannes Koch

Brain Oscillatory Modes as a Proxy of Stroke Recovery

Dimitri Nestor Alice Van De Ville, Olaf Blanke, Silvestro Micera, Friedhelm Christoph Hummel, Takuya Morishita, Elena Beanato, Sylvain Jean-François Harquel, Lisa Aïcha Mireille Julie Fleury, Nathalie Heidi Meyer, Maximilian Jonas Wessel

Background Stroke is the leading cause of long-term disability, making the search for successful rehabilitation treatment one of the most important public health issues. A better understanding of the neural mechanisms underlying impairment and recovery is ...

SAGE Publications2025

White adipose tissue distribution and amount are associated with increased white matter connectivity

Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch, Liana Okudzhava

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Wiley2024

Preserved Corticospinal Tract Revealed by Acute Perfusion Imaging Relates to Better Outcome After Thrombectomy in Stroke

Friedhelm Christoph Hummel, Philipp Johannes Koch

BACKGROUND:The indication for mechanical thrombectomy (MT) in stroke patients with large vessel occlusion has been constantly expanded over the past years. Despite remarkable treatment effects at the group level in clinical trials, many patients remain sev ...

Lippincott Williams & Wilkins2023

Differential Impact of Brain Network Efficiency on Poststroke Motor and Attentional Deficits

Dimitri Nestor Alice Van De Ville, Friedhelm Christoph Hummel, Gabriel Girard, Takuya Morishita, Elena Beanato, Lisa Aïcha Mireille Julie Fleury, Nathalie Heidi Meyer, Maximilian Jonas Wessel, Philip Egger, Philipp Johannes Koch

Background:Most studies on stroke have been designed to examine one deficit in isolation; yet, survivors often have multiple deficits in different domains. While the mechanisms underlying multiple-domain deficits remain poorly understood, network-theoretic ...

2023

Multi-focal Stimulation of the Cortico-cerebellar Loop During the Acquisition of a Novel Hand Motor Skill in Chronic Stroke Survivors

Friedhelm Christoph Hummel, Takuya Morishita, Pablo Maceira Elvira, Manon Chloé Durand-Ruel, Maximilian Jonas Wessel, Philipp Johannes Koch, Laurijn Rianne Draaisma

Impairment of hand motor function is a frequent consequence after a stroke and strongly determines the ability to regain a self-determined life. An influential research strategy for improving motor deficits is the combined application of behavioral trainin ...

2023

NPTX1-related oculomotor apraxia: an intra-hemispheric disconnection disorder

Gabriel Girard, Philipp Johannes Koch

SPRINGER HEIDELBERG2022

Toward individualized medicine in stroke-The TiMeS project: Protocol of longitudinal, multi-modal, multi-domain study in stroke

Jean-Philippe Thiran, Dimitri Nestor Alice Van De Ville, Olaf Blanke, Silvestro Micera, Friedhelm Christoph Hummel, Gabriel Girard, Takuya Morishita, Elena Beanato, Estelle Emeline Raffin, Sylvain Jean-François Harquel

Despite recent improvements, complete motor recovery occurs in < 15% of stroke patients. To improve the therapeutic outcomes, there is a strong need to tailor treatments to each individual patient. However, there is a lack of knowledge concerning the preci ...

FRONTIERS MEDIA SA2022

Evaluating reproducibility and subject-specificity of microstructure-informed connectivity

Jean-Philippe Thiran, Friedhelm Christoph Hummel, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Gabriel Girard, Elda Fischi Gomez, Gian Franco Piredda, Takuya Morishita, Elena Beanato

Tractography enables identifying and evaluating the healthy and diseased brain's white matter pathways from diffusion-weighted magnetic resonance imaging data. As previous evaluation studies have reported significant false-positive estimation biases, recen ...

ACADEMIC PRESS INC ELSEVIER SCIENCE2022

Variability and reproducibility of multi-echo T2 relaxometry: Insights from multi-site, multi-session and multi-subject MRI acquisitions

Jean-Philippe Thiran, Friedhelm Christoph Hummel, Tobias Kober, Tom Hilbert, Erick Jorge Canales Rodriguez, Gabriel Girard, Elda Fischi Gomez, Gian Franco Piredda, Thomas Yu, Takuya Morishita

Quantitative magnetic resonance imaging (qMRI) can increase the specificity and sensitivity of conventional weighted MRI to underlying pathology by comparing meaningful physical or chemical parameters, measured in physical units, with normative values acqu ...

2022

Multifocal stimulation of the cerebro-cerebellar loop during the acquisition of a novel motor skill

Friedhelm Christoph Hummel, Takuya Morishita, Elena Beanato, Maximilian Jonas Wessel, Chang-Hyun Park, Philipp Johannes Koch

Transcranial direct current stimulation (tDCS)-based interventions for augmenting motor learning are gaining interest in systems neuroscience and clinical research. Current approaches focus largely on monofocal motorcortical stimulation. Innovative stimula ...

Nature Research2021