Publications de Valentina Marie Paggi

Optogenetic modulation of peripheral nociceptive neurons with biocompatible optoelectronic implants

Stéphanie Lacour, Bernard Schneider, Ivan Furfaro, Frédéric Pierre Gérald Michoud, Valentina Marie Paggi

Hyperexcitability of peripheral sensory neurons plays a critical role in the development and maintenance of chronic pain. Pharmacological analgesics used in clinics reduce neuronal activity. They often come with non‐negligible side effects. Optogenetic app ...

Wiley2025

A soft, scalable and adaptable multi-contact cuff electrode for targeted peripheral nerve modulation

Silvestro Micera, Stéphanie Lacour, Katia Galan, Ivan Furfaro, Florian Dylan Fallegger, Valentina Marie Paggi, Olivier Didier Christian Rizzo

Background: Cuff electrodes target various nerves throughout the body, providing neuromodulation therapies for motor, sensory, or autonomic disorders. However, when using standard, thick silicone cuffs, fabricated in discrete circular sizes, complications ...

2024

Cardiovascular Response to Intraneural Right Vagus Nerve Stimulation in Adult Minipig

Silvestro Micera, Stéphanie Lacour, Valentina Marie Paggi

Objective: This study explored intraneural stimulation of the right thoracic vagus nerve (VN) in sexually mature male minipigs to modulate safe heart rate and blood pressure response. Material and Methods: We employed an intraneural electrode designed for ...

ELSEVIER2024

Soft bioelectronic technologies for selective and multimodal peripheral nerve interfaces

Valentina Marie Paggi

The peripheral nervous system (PNS) regulates the exchange of sensory information and motor commands between the body and the central nervous system. Further, through the autonomic nervous system, the PNS plays a pivotal role in controlling vital physiolog ...

EPFL2023

Decoding bladder state from pudendal intraneural signals in pigs

Silvestro Micera, Stéphanie Lacour, Leonardo Pollina, Ivo Strauss, Valentina Marie Paggi

Neuroprosthetic devices used for the treatment of lower urinary tract dysfunction, such as incontinence or urinary retention, apply a pre-set continuous, open-loop stimulation paradigm, which can cause voiding dysfunctions due to neural adaptation. In the ...

2023

Neural Stimulation Hardware for the Selective Intrafascicular Modulation of the Vagus Nerve

Silvestro Micera, Stéphanie Lacour, Valentina Marie Paggi

The neural stimulation of the vagus nerve is able to modulate various functions of the parasympathetic response in different organs. The stimulation of the vagus nerve is a promising approach to treating inflammatory diseases, obesity, diabetes, heart fail ...

Ieee-Inst Electrical Electronics Engineers Inc2023

Wireless closed-loop optogenetics across the entire dorsoventral spinal cord in mice

Stéphanie Lacour, Grégoire Courtine, Quentin Barraud, Léonie Asboth, Ileana Ozana Jelescu, Ivan Furfaro, Kyungjin Kim, Jérôme Gandar, Frédéric Pierre Gérald Michoud, Claudia Kathe

Optoelectronic systems can exert precise control over targeted neurons and pathways throughout the brain in untethered animals, but similar technologies for the spinal cord are not well established. In the present study, we describe a system for ultrafast, ...

NATURE PORTFOLIO2022

Compliant peripheral nerve interfaces

Silvestro Micera, Stéphanie Lacour, Outman Akouissi, Valentina Marie Paggi

Peripheral nerve interfaces (PNIs) record and/or modulate neural activity of nerves, which are responsible for conducting sensory-motor information to and from the central nervous system, and for regulating the activity of inner organs. PNIs are used both ...

IOP PUBLISHING LTD2021

Stretchable cuff device

Giuseppe Schiavone, Nicolas Vachicouras, Florian Dylan Fallegger, Ludovic Serex, Valentina Marie Paggi

The invention features a cuff device comprising a support having a first end, a second end and an elongated body in between; connection means for electrical, magnetic and/or fluidic magnetic connection with external devices; at least one of i) an electrode ...

2020

Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants

Stéphanie Lacour, Nicolas Vachicouras, Florian Dylan Fallegger, Christina Myra Tringides, Jennifer Mary Adrienne Alice Macron, Valentina Marie Paggi, Yohann Daniel André Thenaisie

Auditory brainstem implants (ABIs) provide sound awareness to deaf individuals who are not candidates for the cochlear implant. The ABI electrode array rests on the surface of the cochlear nucleus (CN) in the brainstem and delivers multichannel electrical ...

2019