Personne
Suiyang Liao
Cette personne n’est plus à l’EPFL
Publications associées (7)
Influence of structural dynamics on cell uptake investigated with single-chain polymeric nanoparticles
Francesco Stellacci, Lixia Wei, Arthur Eliot Bouchez, Suiyang Liao
Most nanoparticles' parameters affect their interactions with cells. To date, all the parameters studied are basically static (e.g., size, shape, ligands, and charge). This is unfortunate, because proteins have struc-tural dynamics that most nanoparticles ...
CELL PRESS2023Single-Chain Nanoparticles for Intracellular Drug Delivery
Single-chain nanoparticles (SCNPs) are a type of polymeric nanoparticles formed by collapsing/folding individual polymer chains via intra-molecular interactions. Their emergence holds promise to construct sub-20 nm polymeric nanoparticles with defined stru ...
EPFL2022Control and Characterization of the Compactness of Single-Chain Nanoparticles
Francesco Stellacci, Luciano Andres Abriata, Lixia Wei, Suiyang Liao
Polymers when self-cross-linked into single-chain nanoparticles bear some resemblance to folded proteins; yet proteins have clear energy landscapes that determine precisely folded structures, while single-chain polymer nanoparticles (SCNPs) have more undef ...
AMER CHEMICAL SOC2021Comparative characterisation of non-monodisperse gold nanoparticle populations by X-ray scattering and electron microscopy
Francesco Stellacci, Stefan Guldin, Ye Yang, Zhi Luo, Suiyang Liao, Runzhang Qi
Accurate nanoparticle size determination is essential across various research domains, with many functionalities in nanoscience and biomedical research being size-dependent. Although electron microscopy is capable of resolving a single particle down to the ...
2020Quantification of surface composition and segregation on AuAg bimetallic nanoparticles by MALDI MS
Francesco Stellacci, Zhi Luo, Suiyang Liao
In this work we show that it is possible to use MALDI-TOF as a tool to quantify the atomic composition and to describe the phase segragation of the surface of ligand-coated, bimetallic AuAg nanoparticles. Our investigation shows that AuAg nanoparticles of ...
ROYAL SOC CHEMISTRY2020On the effect of ligand shell heterogeneity on nanoparticle/protein binding thermodynamics
Francesco Stellacci, Ahmet Bekdemir, Suiyang Liao
Nonspecific protein adhesion to nanoparticle (NP) has been proven to have important implications in nanomedicine. However, there are only a few examples of careful studies relating protein binding thermodynamics to NP physicochemical features. In particula ...
2019Polymeric Micelles Loading Proteins through Concurrent Ion Complexation and pH-Cleavable Covalent Bonding for In Vivo Delivery
Francesco Stellacci, Suiyang Liao
Protein drugs have great potential as targeted therapies, yet their application suffers from several drawbacks, such as instability, short half-life, and adverse immune responses. Thus, protein delivery approaches based on stimuli-responsive nanocarriers c ...
WILEY-V C H VERLAG GMBH2019