Publications de Elie Charles Eugène Dheilly

Nongenetic Evolution Drives Lung Adenocarcinoma Spatial Heterogeneity and Progression

Elisa Oricchio, Aaron Simone Petruzzella, Elena Battistello, Elie Charles Eugène Dheilly

Cancer evolution determines molecular and morphologic intratumor heterogeneity and challenges the design of effective treatments. In lung adenocarcinoma, disease progression and prognosis are associated with the appearance of morphologically diverse tumor ...

AMER ASSOC CANCER RESEARCH2021

De novo protein design enables the precise induction of RSV-neutralizing antibodies

Luciano Andres Abriata, Bruno Emanuel Ferreira De Sousa Correia, Elisa Oricchio, Sandrine Madeleine Suzanne Georgeon, Jaume Bonet Martinez, Fabian Sesterhenn, Stéphane Rosset, Che Yang, Patricia Corthésy Henrioud, Sabrina Susan Vollers

De novo protein design has been successful in expanding the natural protein repertoire. However, most de novo proteins lack biological function, presenting a major methodological challenge. In vaccinology, the induction of precise antibody responses remain ...

American Association for the Advancement of Science2020

Cathepsin S Regulates Antigen Processing and T Cell Activity in Non-Hodgkin Lymphoma

Bruno Emanuel Ferreira De Sousa Correia, George Coukos, Elisa Oricchio, Natalya Katanayeva, Julien Racle, Jessica Sordet, Sarah Wehrle, Elena Battistello, Stephanie Jocelyne Sungalee, Elie Charles Eugène Dheilly

Genomic alterations in cancer cells can influence the immune system to favor tumor growth. In non-Hodgkin lymphoma, physiological interactions between B cells and the germinal center microenvironment are coopted to sustain cancer cell proliferation. We fou ...

2020

Pan-SRC kinase inhibition blocks B-cell receptor oncogenic signaling in non-Hodgkin lymphoma

Olivier Michielin, Elisa Oricchio, Daniele Tavernari, Natalya Katanayeva, Elena Battistello, Maria Christine Donaldson, Elie Charles Eugène Dheilly, Giovanni Ciriello

2018

Tumor-Directed Blockade of CD47 with Bispecific Antibodies Induces Adaptive Antitumor Immunity

Elie Charles Eugène Dheilly

2018