Publications de Vincenzo Caroprese

Interface flexibility controls the nucleation and growth of supramolecular networks

Georg Fantner, Maartje Martina Cornelia Bastings, Navid Asmari Saadabad, Cem Tekin, Veronika Cencen, Vincenzo Caroprese

Supramolecular networks are abundantly present in nature and, like crystalline materials, often develop from an initial nucleation site, followed by growth based on directional interactions between components. Traditionally, the binding strength and direct ...

2025

Evolution of multivalent supramolecular assemblies of aptamers with target-defined spatial organization

Maartje Martina Cornelia Bastings, Yoan Désiré Duhoo, Cem Tekin, Vincenzo Caroprese

Rapid identification of neutralizing molecules against new and mutating viruses is key to efficiently combating biorisk. Current binder identification techniques use a monovalent library of potential binders. Interestingly, proteins on pathogens are often ...

2025

Dynamic Surface Interactions Enable the Self-Assembly of Perfect Supramolecular Crystals

Maartje Martina Cornelia Bastings, Cem Tekin, Vincenzo Caroprese

Supramolecular crystals arise from noncovalent interactions between macromonomers and allow for the engineering of dynamic functional materials. For two-dimensional (2D) crystals, the substrate surface can induce the formation of new polymorphs not availab ...

2024

Coarse grain modelling of DNA self-assembly over multiple scales

Vincenzo Caroprese

The integration of DNA into bottom-up nanotechnology has catalyzed a revolution in achieving nanometric precision through self-assembly. This leap forward is instrumental in broadening the horizons for constructing at the nanoscale, harnessing the predicta ...

EPFL2024

Modulating the DNA/Lipid Interface through Multivalent Hydrophobicity

Maartje Martina Cornelia Bastings, Diana Kornelia Morzy, Vincenzo Caroprese

Lipids and nucleic acids are two of the most abundant components of our cells, and both molecules are widely used as engineering materials for nanoparticles. Here, we present a systematic study of how hydrophobic modifications can be employed to modulate t ...

American Chemical Society (ACS)2024

Interplay of the mechanical and structural properties of DNA nanostructures determines their electrostatic interactions with lipid membranes

Maartje Martina Cornelia Bastings, Cem Tekin, Diana Kornelia Morzy, Vincenzo Caroprese

Nucleic acids and lipids function in close proximity in biological processes, as well as in nanoengineered constructs for therapeutic applications. As both molecules carry a rich charge profile, and frequently coexist in complex ionic solutions, the electr ...

ROYAL SOC CHEMISTRY2023

Multivalent Pattern Recognition through Control of Nano-Spacing in Low-Valency Super-Selective Materials

Maartje Martina Cornelia Bastings, Kaltrina Paloja, Hale Bila, Vincenzo Caroprese

Super-selective multivalent ligand-receptor interactions display a signature step-like onset in binding when meeting a characteristic density of target receptors. Materials engineered for super-selective binding generally display a high number of flexible ...

AMER CHEMICAL SOC2022

Selective Integrin alpha(5)beta(1) Targeting through Spatially Constrained Multivalent DNA-Based Nanoparticles

Maartje Martina Cornelia Bastings, Eva Eugene Kurisinkal, Diana Kornelia Morzy, Marianna Mainardi Koga, Vincenzo Caroprese

Targeting cells specifically based on receptor expression levels remains an area of active research to date. Selective binding of receptors cannot be achieved by increasing the individual binding strength, as this does not account for differing distributio ...

MDPI2022