Publications de Nadia Bresciani

Asparagine protects pericentral hepatocytes during acute liver injury

Kristina Schoonjans, Alessia Perino, Hadrien Charles Edouard Demagny, Antoine Jalil, Ece Yildiz, Yu Sun, Nadia Bresciani

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic activity of asparagine synthetase (ASNS). While ASNS and asparagine have been implicated in the response to numerous metabolic stressors in cultured cells, the in vivo ...

AMER SOC CLINICAL INVESTIGATION INC2023

The Slc25a47 locus is a novel determinant of hepatic mitochondrial function implicated in liver fibrosis

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Xiaoxu Li, Vera Monica Lemos Da Silva, Hadrien Charles Edouard Demagny, Hao Li, Yu Sun, Nadia Bresciani

Background & Aims: Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological r ...

ELSEVIER2022

Dissecting the role of the mitochondrial carrier SLC25A47

Nadia Bresciani

Transporters of the SLC25 mitochondrial carrier superfamily bridge cytoplasmic and mitochondrial metabolism by channeling metabolites across mitochondrial membranes and are pivotal for metabolic homeostasis. Despite their physiological relevance as gatekee ...

EPFL2022

Central anorexigenic actions of bile acids are mediated by TGR5

Kristina Schoonjans, Alessia Perino, Laura Alejandra Velazquez Villegas, Qingyao Huang, Yu Sun, Nadia Bresciani

Bile acids (BAs) are signalling molecules that mediate various cellular responses in both physiological and pathological processes. Several studies report that BAs can be detected in the brain, yet their physiological role in the central nervous system is ...

2021