Publications de Angela Madurga Alonso

Lat-based nk cars and their use

Angela Madurga Alonso, Mathieu Girardin, Jörg Hülsken

The invention relates to chimeric antigen receptor constructs and their use for treatments and therapies. Further disclosed are methods of treating and/or preventing a disease, such as e.g. a cancer, an infectious disease, an inflammatory or inflammation-i ...

2024

Metabolic dependencies of metastasis-initiating cells in female breast cancer

Albert Santamaria Martinez, Pierre Vincent Dessen, Jörg Hülsken, Laurent Nam Ky Beziaud, Angela Madurga Alonso, Candice Megan T Young

Understanding the mechanisms that enable cancer cells to metastasize is essential in preventing cancer progression. Here we examine the metabolic adaptations of metastasis-initiating cells (MICs) in female breast cancer and how those shape their metastatic ...

Nature Portfolio2023

IFNγ-induced stem-like state of cancer cells as a driver of metastatic progression following immunotherapy

Maxim Norkin, Angela Madurga Alonso, Jörg Hülsken, Laurent Nam Ky Beziaud

Despite the remarkable success of immune checkpoint blockade (ICB) therapy, most cancer patients still do not respond. We now find that immunotherapy can induce stem-like properties in tumors. Using mouse models of breast cancer, we observe that cancer ste ...

Elsevier BV2023

Development of a novel Chimeric Antigen Receptor (CAR) for its use in Natural Killer (NK) cells for cancer treatment and beyond

Angela Madurga Alonso

The use of CAR technologies has revolutionized cancer treatment. Their unprecedented efficacy against B cell malignancies has opened the doors for a lot of excitement and research in the field. These synthetic receptors are composed of an antigen recogniti ...

EPFL2023