Publications de Sundar Ram Naganathan

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

Andrew Charles Oates, Petr Strnad, Laurel Ann Rohde, Daniele Soroldoni, Sundar Ram Naganathan, Arianne Bercowsky Rama

Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through the presomitic m ...

2024

Preparation of Single-Somite Explants from Zebrafish Embryos

Andrew Charles Oates, Sundar Ram Naganathan

The body axis of vertebrate embryos is periodically subdivided into 3D multicellular units called somites. While genetic oscillations and molecular prepatterns determine the initial length-scale of somites, mechanical processes have been implicated in sett ...

JOURNAL OF VISUALIZED EXPERIMENTS2022

Left-right symmetry of zebrafish embryos requires somite surface tension

Andrew Charles Oates, Marko Popovic, Sundar Ram Naganathan

The body axis of vertebrate embryos is periodically segmented into bilaterally symmetric pairs of somites(1,2). The anteroposterior length of somites, their position and left-right symmetry are thought to be molecularly determined before somite morphogenes ...

NATURE PORTFOLIO2022

Hand2 delineates mesothelium progenitors and is reactivated in mesothelioma

Sundar Ram Naganathan

The mesothelium lines body cavities and surrounds internal organs, widely contributing to homeostasis and regeneration. Mesothelium disruptions cause visceral anomalies and mesothelioma tumors. Nonetheless, the embryonic emergence of mesothelia remains inc ...

Nature Research2022

Patterning and mechanics of somite boundaries in zebrafish embryos

Andrew Charles Oates, Sundar Ram Naganathan

The body axis of vertebrates is subdivided into repetitive compartments called somites, which give rise primarily to the segmented architecture of the musculoskeletal system in the adult body. Somites form in a sequential and rhythmic manner in embryos and ...

2020

Morphogenetic degeneracies in the actomyosin cortex

Sundar Ram Naganathan

One of the great challenges in biology is to understand the mechanisms by which morphogenetic processes arise from molecular activities. We investigated this problem in the context of actomyosin-based cortical flow in C. elegans zygotes, where large-scale ...

ELIFE SCIENCES PUBLICATIONS LTD2018

The Sweetness of Embryonic Elongation and Differentiation

Andrew Charles Oates, Sundar Ram Naganathan

Metabolic pathways play a vital yet poorly understood role in embryogenesis. In this issue of Developmental Cell, Bulusu et al. (2017) and Oginuma et al. (2017) provide insights into the intricate relationship between metabolism and morphogenesis, showing ...

Cell Press - Elsevier2017