Publications de Carolina Brito Carvalho dos Santos

Testing Theories of the Glass Transition with the Same Liquid but Many Kinetic Rules

Matthieu Wyart, Carolina Brito Carvalho dos Santos

We study the glass transition by exploring a broad class of kinetic rules that can significantly modify the normal dynamics of supercooled liquids while maintaining thermal equilibrium. Beyond the usual dynamics of liquids, this class includes dynamics in ...

Amer Physical Soc2024

Infinitesimal asphericity changes the universality of the jamming transition

Matthieu Wyart, Carolina Brito Carvalho dos Santos

The jamming transition of non-spherical particles is fundamentally different from the spherical case. Non-spherical particles are hypostatic at their jamming points, while isostaticity is ensured in the case of the jamming of spherical particles. This stru ...

IOP PUBLISHING LTD2020

Jamming with Tunable Roughness

Matthieu Wyart, Carolina Brito Carvalho dos Santos

We introduce a new model to study the effect of surface roughness on the jamming transition. By performing numerical simulations, we show that for a smooth surface, the jamming transition density and the contact number at the transition point both increase ...

AMER PHYSICAL SOC2020

Direct coupling analysis of epistasis in allosteric materials

Matthieu Wyart, Riccardo Ravasio, Carolina Brito Carvalho dos Santos, Barbara Bravi

In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable interest in inferring them from sequence alignment data. Currently, differen ...

2020

Fast generation of ultrastable computer glasses by minimization of an augmented potential energy

Matthieu Wyart, Wencheng Ji, Carolina Brito Carvalho dos Santos

We present a model and protocol that enable the generation of extremely stable computer glasses at minimal computational cost. The protocol consists of an instantaneous quench in an augmented potential energy landscape, with particle radii as additional de ...

AMER PHYSICAL SOC2019

Mechanics of Allostery: Contrasting the Induced Fit and Population Shift Scenarios

Matthieu Wyart, Solange Marie Flatt, Carolina Brito Carvalho dos Santos, Stefano Zamuner, Riccardo Ravasio

In allosteric proteins, binding a ligand can affect function at a distant location, for example, by changing the binding affinity of a substrate at the active site. The induced fit and population shift models, which differ by the assumed number of stable c ...

CELL PRESS2019

Allostery in Its Many Disguises: From Theory to Applications

Matthieu Wyart, Giulia Palermo, Carolina Brito Carvalho dos Santos, Jingshi Li, Riccardo Ravasio, Jing Li

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, andmetabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mec ...

CELL PRESS2019

Universality of jamming of nonspherical particles

Matthieu Wyart, Carolina Brito Carvalho dos Santos

Amorphous packings of nonspherical particles such as ellipsoids and spherocylinders are known to be hypostatic: The number of mechanical contacts between particles is smaller than the number of degrees of freedom, thus violating Maxwell's mechanical stabil ...

National Academy of Sciences2018

Principles for Optimal Cooperativity in Allosteric Materials

Matthieu Wyart, Carolina Brito Carvalho dos Santos, Riccardo Ravasio

2018

Theory for Swap Acceleration near the Glass and Jamming Transitions for Continuously Polydisperse Particles

Matthieu Wyart, Carolina Brito Carvalho dos Santos

American Physical Society2018