Publications de Yang Zhao | EPFL Graph Search

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

Li Tang, Lucia Bonati, Mei-Wen Peng, Rongrong Li, Yugang Guo, Yang Zhao, Bing Feng

Current cancer immunotherapy predominately focuses on eliciting type 1 immune responses fighting cancer; however, long-term complete remission remains uncommon1,2. A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1 ...

2024

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Li Tang, Yugang Guo, Yang Zhao, Yuqing Xie, Bing Feng, Xiaomeng Hu

The success of chimeric antigen receptor (CAR) T cell therapy in treating several hematopoietic malignancies has been difficult to replicate in solid tumors, in part because of T cell exhaustion and eventually dysfunction. To counter T cell dysfunction in ...

Nature Portfolio2024

Il-10 expressing cells for enhanced cancer immunotherapies

Li Tang, Yugang Guo, Yang Zhao

The present invention relates generally to the field of anti-cancer therapy, in particular to the use of adoptive T cell transfer therapy for treating cancer, in particular sold tumors. More specifically, the present invention relates to immune cells compr ...

2023

Ultrafast Energy Transfer from Photoexcited Tryptophan to the Haem in Cytochrome c

Majed Chergui, Giulia Fulvia Mancini, Camila Bacellar Cases Da Silveira, Dominik Kinschel, Oliviero Cannelli, Rebecca Ann Ingle, Yang Zhao, Jérémy Raymond Jean Maurice Rouxel

: We report femtosecond Fe K-edge absorption (XAS) and nonresonant X-ray emission (XES) spectra of ferric cytochrome C (Cyt c) upon excitation of the haem (>300 nm) or mixed excitation of the haem and tryptophan (

2023

Countering T cell exhaustion and senescence for enhanced adoptive T cell therapies against solid tumors

Yang Zhao

CAR-T cell therapy has shown remarkable success in treating hematopoietic malignancies, but its efficacy in solid tumors is limited by T cell dysfunction, including exhaustion and senescence. In this study, we designed metabolically armored CAR-T cells to ...

EPFL2023

Metabolic reprogramming of terminally exhausted CD8(+) T cells by IL-10 enhances anti-tumor immunity

Li Tang, Yugang Guo, Yang Zhao, Min Gao, Bing Feng

Tang and colleagues show that a half-life-extended IL-10-Fc fusion protein acts directly on terminally exhausted PD1(+)TIM-3(+)CD8(+) T cells to enhance their proliferation and effector function by reprogramming the cellular metabolism to oxidative phospho ...

2021

Variational approach to time-dependent fluorescence of a driven qubit

Yang Zhao

We employ the Dirac-Frenkel variational principle and the multiple Davydov ansatz to study time-dependent fluorescence spectra of a driven qubit in the weak to strong qubit-reservoir coupling regimes, where both the Rabi frequency and the spontaneous decay ...

AMER PHYSICAL SOC2020

Complex magnetic incommensurability and electronic charge transfer through the ferroelectric transition in multiferroic Co3TeO6

Helmuth Berger, Yang Zhao

Polarized and unpolarized neutron diffractions have been carried out to investigate the nature of the magnetic structures and transitions in monoclinic Co3TeO6. As the temperature is lowered below 26 K long range order develops, which is fully incommensura ...

Springer Nature2017

Dynamic behavior of rock during its post failure stage in SHPB tests

Yang Zou, Yang Zhao, Xin Cai

In order to investigate the micro-process and inner mechanism of rock failure under impact loading, the laboratory tests were carried out on an improved split Hopkinson pressure bar (SHPB) system with synchronized measurement devices including a high-speed ...

Elsevier Science Bv2017

Interplay between the magnetic and electric degrees of freedom in multiferroic Co3TeO6

Helmuth Berger, Yang Zhao

Neutron diffraction, magnetic susceptibility, specific heat, and dielectric constant measurements of single-crystal Co3TeO6 have been measured to study the interplay between the ferroelectricity and magnetic order. Long-range incommensurate magnetic order ...

2012