Publications de Gaby El Alam | EPFL Graph Search

High-content phenotypic analysis of a C. elegans recombinant inbred population identifies genetic and molecular regulators of lifespan

Johan Auwerx, Laurent Mouchiroud, Xiaoxu Li, Maroun Bou Sleiman, Elena Katsyuba, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam, Jean-David Horacio Morel

Lifespan is influenced by complex interactions between genetic and environmental factors. Studying those factors in model organisms of a single genetic background limits their translational value for humans. Here, we mapped lifespan determinants in 85 C. e ...

2024

Hepatic lipid overload triggers biliary epithelial cell activation via E2Fs

Johan Auwerx, Kristina Schoonjans, Alessia Perino, Antoine Jalil, Giovanni Sorrentino, Ece Yildiz, Gaby El Alam

During severe or chronic hepatic injury, biliary epithelial cells (BECs) undergo rapid activation into proliferating progenitors, a crucial step required to establish a regenerative process known as ductular reaction (DR). While DR is a hallmark of chronic ...

eLIFE SCIENCES PUBL LTD2023

Tetracycline-induced mitohormesis mediates disease tolerance against influenza

Johan Auwerx, Davide D'Amico, Nicola Harris, Elena Katsyuba, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Yang Li, Gaby El Alam

Mitohormesis defines the increase in fitness mediated by adaptive responses to mild mitochondrial stress. Tetracyclines inhibit not only bacterial but also mitochondrial translation, thus imposing a low level of mitochondrial stress on eukaryotic cells. We ...

AMER SOC CLINICAL INVESTIGATION INC2022

Article Multi-omics analysis identifies essential regulators of mitochondrial stress response in two wild-type C. elegans strains

Johan Auwerx, Maroun Bou Sleiman, Wen Gao, Yang Li, Amélia Lalou, Gaby El Alam

The mitochondrial unfolded protein response (UPRmt) is a promising pharmacological target for aging and age-related diseases. However, the integrative analysis of the impact of UPRmt activation on different signaling layers in animals with different geneti ...

CELL PRESS2022

Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration

Kristina Schoonjans, Alessia Perino, Maroun Bou Sleiman, Giovanni Sorrentino, Ece Yildiz, Gaby El Alam

BACKGROUND & AIMS: Renewal and patterning of the intestinal epithelium is coordinated by intestinal stem cells (ISCs); dietary and metabolic factors provide signals to the niche that control ISC activity. Bile acids (BAs), metabolites in the gut, signal nu ...

2020