Personne
Yimon Aye
Publications associées (37)
Neighborhood watch: tools for defining locale-dependent subproteomes and their contextual signaling activities
Transient associations between numerous organelles-e.g., the endoplasmic reticulum and the mitochondria-forge highly-coordinated, particular environments essential for cross-compartment information flow. Our perspective summarizes chemical-biology tools th ...
ROYAL SOC CHEMISTRY2020The mRNA-Binding Protein HuR Is a Kinetically-Privileged Electrophile Sensor
Yimon Aye, Jesse Poganik, Yi Zhao, Alexandra Krina Van Hall-Beauvais
The key mRNA-binding proteins HuR and AUF1 are reported stress sensors in mammals. Intrigued by recent reports of sensitivity of these proteins to the electrophilic lipid prostaglandin A2 and other redox signals, we here examined their sensing abilities to ...
2020Empowering Global Chemical Biology at the Dawn of the New Decade
On January 22-24, 2020, scientific luminaries across the far-flung corners of chemical biology gathered in Geneva, Switzerland, to deliver their latest and greatest discoveries in the field. Generously supported by the Swiss National Science Foundation (SN ...
AMER CHEMICAL SOC2020Electrophile Signaling and Emerging Immuno- and Neuro-modulatory Electrophilic Pharmaceuticals
With a lipid-rich environment and elevated oxygen consumption, the central nervous system (CNS) is subject to intricate regulation by lipid-derived electrophiles (LDEs). Investigations into oxidative damage and chronic LDE generation in neural disorders ha ...
FRONTIERS MEDIA SA2020The more the merrier: how homo-oligomerization alters the interactome and function of ribonucleotide reductase
Stereotyped as a nexus of dNTP synthesis, the dual-subunit enzyme - ribonucleotide reductase (RNR) - is coming into view as a paradigm of oligomerization and moonlighting behavior. In the present issue of `omics', we discuss what makes the larger subunit o ...
ELSEVIER SCI LTD2020Where Electrophile Signaling and Covalent Ligand-Target Mining Converge
Interests in learning how to engineer most effective covalent ligands, identify novel functional targets, and define precise mechanism-of-action are rapidly growing in both academia and pharmaceutical industries. We here illuminate the establishment of a m ...
SWISS CHEMICAL SOC2020Getting the Right Grip? How Understanding Electrophile Selectivity Profiles Could Illuminate Our Understanding of Redox Signaling
Recent Advances: Herein, we focus on the first step of this process, electrophile sensing. Electrophile sensing is typically a deceptively simple reaction between the thiol of a protein cysteine, of which there are around 200,000 in the human proteome, and ...
MARY ANN LIEBERT, INC2019Breaking the Fourth Wall: Modulating Quaternary Associations for Protein Regulation and Drug Discovery
Protein-protein interactions (PPIs) are an effective means to orchestrate intricate biological processes required to sustain life. Approximately 650000 PPIs underlie the human interactome; thus underscoring its complexity and the manifold signaling outputs ...
WILEY-V C H VERLAG GMBH2019