Publications de Giovanni D'Angelo

Single cell lipid biology

Giovanni D'Angelo, Antonino Asaro, Agostina Crotta Asis

Lipids are major cell constituents endowed with astonishing structural diversity. The pathways responsible for the assembly and disposal of different lipid species are energetically demanding, and genes encoding lipid metabolic factors and lipid-related pr ...

2025

Optically Trapped Nano-diamond Quantum Sensors to Explore Viscoelastic Properties and Redox Metabolism of Cells in Cardiac Fibrosis

Giovanni D'Angelo, Agostina Crotta Asis

The impact of mechanical stimuli on cell organelles is unexplored due to lack of research tools. This study introduces a novel method combining nanodiamond quantum sensing and optical trapping to explore redox metabolism and viscoelastic properties in card ...

Optical Society of America2025

Alterations of lipid homeostasis in morbid obese patients are partly reversed by bariatric surgery

Giovanni D'Angelo

Besides its beneficial effect on weight loss, gastric bypass surgery (GBS) may impact the circulating levels of phospho- and sphingolipids. However, long-term effects have not been explored. To investigate alterations in lipidomic signatures associated wit ...

2024

The conformational plasticity of structurally unrelated lipid transport proteins correlates with their mode of action

Giovanni D'Angelo, Charlotte Julie Caroline Gehin

AU Lipid: Pleaseconfirmthatallheadinglevelsarerepresentedcorrectly transfer proteins (LTPs) are key players in cellular homeostasis : and regulation, as they coordinate the exchange of lipids between different cellular organelles. Despite their importance, ...

2024

Inactivation mechanisms of influenza A virus under pH conditions encountered in aerosol particles as revealed by whole-virus HDX-MS

Athanasios Nenes, Tamar Kohn, Giovanni D'Angelo, Kalliopi Violaki, Ghislain Gilles Jean-Michel Motos, Aline Laetitia Schaub, Walter Hugentobler, Shannon Christa David, Jonathan Paz Montoya

Multiple respiratory viruses, including influenza A virus (IAV), can be transmitted via expiratory aerosol particles, and aerosol pH was recently identified as a major factor influencing airborne virus infectivity. Indoors, small exhaled aerosols undergo r ...

2023

The lipotype hypothesis

Giovanni D'Angelo, Gioele La Manno

Giovanni D'Angelo and Gioele La Manno present the concept of lipotypes, and suggest that lipid composition is an important regulator of cell fate. ...

NATURE PORTFOLIO2023

ER-Golgi membrane contact sites control the formation of plasma membrane lipid nanodomains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Giovanni D'Angelo, Muhammad Umair Anwar, Oksana Andrei Sergeeva

AMER SOC CELL BIOLOGY2023

CERT1 mutations perturb human development by disrupting sphingolipid homeostasis

Bruno Lemaitre, Paolo De Los Rios, Giovanni D'Angelo, Evelyne Ruchti, Sylvia Ho, Samuel Rommelaere, Charlotte Julie Caroline Gehin, Laura Capolupo, Greta Limoni, Huixin Guo

Neural differentiation, synaptic transmission, and action potential propagation depend on membrane sphingolipids, whose metabolism is tightly regulated. Mutations in the ceramide transporter CERT (CERT1), which is involved in sphingolipid biosynthesis, are ...

American Society for Clinical Investigation2023

Sphingolipids control dermal fibroblast heterogeneity

Giovanni D'Angelo, Gioele La Manno, Olivier Burri, Romain Guiet, Sylvia Ho, Alex Russell Lederer, Laura Capolupo, Irina Khven, Galina Glousker

Human cells produce thousands of lipids that change during cell differentiation and can vary across individual cells of the same type. However, we are only starting to characterize the function of these cell-to-cell differences in lipid composition. Here, ...

American Association for the Advancement of Science2022

ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Giovanni D'Angelo, Laura Capolupo, Francisco De Magalhães Sarmento R De Mesquita, Muhammad Umair Anwar, Oksana Andrei Sergeeva, Audrey Geneviève Chuat, Triana Amen

To promote infections, pathogens exploit host cell machineries such as structural elements of the plasma membrane. Studying these interactions and identifying molecular players are ideal for gaining insights into the fundamental biology of the host cell. H ...

Cell Press - Elsevier2022