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Xavier Fernandez Cassi

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Publications associées (10)

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Comparison of Three Viral Nucleic Acid Preamplification Pipelines for Sewage Viral Metagenomics

Tamar Kohn, Xavier Fernandez Cassi

Viral metagenomics is a useful tool for detecting multiple human viruses in urban sewage. However, more refined protocols are required for its effective use in disease surveillance. In this study, we investigated the performance of three different preampli ...

2024

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Throughout the global COVID-19 pandemic, SARS-CoV-2 genetic variants of concern (VOCs) have repeatedly and independently arisen. VOCs are characterized by increased transmissibility, increased virulence, or reduced neutralization by antibodies obtained fro ...

2022

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Waterborne enteric viruses in lakes, especially at recreational water sites, may have a negative impact on human health. However, their fate and transport in lakes are poorly understood. In this study, we propose a coupled water quality and quantitative mi ...

2022

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Norovirus is the most acute species among the viruses studied according to the simulations while enterovirus poses the least danger. The relative distance to the contamination sources, wind conditions as well as inactivation rates are essential in determin ...

2022

Wastewater monitoring outperforms case numbers as a tool to track COVID-19 incidence dynamics when test positivity rates are high

Tamar Kohn, Xavier Fernandez Cassi, Joseph Chadi Benoit Lemaitre, Federica Cariti, Alex Tunas Corzon, Timothy R. Julian, Carola Bänziger

Wastewater-based epidemiology (WBE) has been shown to coincide with, or anticipate, confirmed COVID-19 case numbers. During periods with high test positivity rates, however, case numbers may be underreported, whereas wastewater does not suffer from this li ...

2021

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The emergence of SARS-CoV-2 mutants with altered transmissibility, virulence, or immunogenicity emphasizes the need for early detection and epidemiological surveillance of genomic variants. Wastewater samples provide an opportunity to assess circulating vi ...

2021

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We investigated SARS-CoV2 spread in the Canton of Ticino, in Switzerland, at the very beginning of the pandemic (end of February 2020 - beginning of March 2020) analyzing wastewater samples. We compared data obtained from clinical testing and wastewater an ...

2021

Wastewater-based estimation of the effective reproductive number of SARS-CoV-2

Tamar Kohn, Krista Rule Wigginton, Xavier Fernandez Cassi, Timothy R. Julian

Background The effective reproductive number, Re, is a critical indicator to monitor disease dynamics, inform regional and national policies, and estimate the effectiveness of interventions. It describes the average number of new infections caused by a sin ...

2021

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Waterborne viruses are responsible for numerous diseases and are abundant in aquatic systems. Understanding the fate of viruses in natural systems has important implications for human health. This research quantifies the uptake of bacteriophage T4 and the ...

2020

Acute infectious gastroenteritis is an important illness worldwide, especially on children, with viruses accounting for approximately 70% of the acute cases. A high number of these cases have an unknown etiological agent and the rise of next generation seq ...

MDPI2020