Publications de Alexandre Gauthier Aurèle Mayran

WNT signaling coordinately controls mouse limb bud outgrowth and establishment of the digit-interdigit pattern

Alexandre Gauthier Aurèle Mayran, Lucille Delisle

Self-organization, such as the emergence of a pattern from a homogenous state, is a fascinating property of biological systems. Early limb bud outgrowth and patterning in mice are controlled by a robust and self-regulatory signaling system, and initiation ...

The Company of Biologists2025

Size-dependent temporal decoupling of morphogenesis and transcriptional programs in pseudoembryos

Denis Duboule, Alexandre Gauthier Aurèle Mayran, Lucille Delisle

Understanding the interplay between cell fate specification and morphogenetic changes remains a challenge in developmental biology. Gastruloids, stem cell models of postimplantation mammalian development, provide a platform to address this question. Here, ...

American Association for the Advancement of Science (AAAS)2025

CTCF-dependent insulation of Hoxb13 and the heterochronic control of tail length

Denis Duboule, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Lucille Delisle, Fabrice Daniel Darbellay, Célia Corinne Renée Bochaton, Pierre Osteil

Mammalian tail length is controlled by several genetic determinants, among which are Hox13 genes, whose function is to terminate the body axis. Accordingly, the precise timing in the transcriptional activation of these genes may impact upon body length. Un ...

National Academy of Sciences2024

Multimodal characterization of murine gastruloid development

Matthias Lütolf, Alexandre Gauthier Aurèle Mayran, Stefano Davide Vianello, Raphaël Ortiz

Gastruloids are 3D structures generated from pluripotent stem cells recapitulating fundamental principles of embryonic pattern formation. Using single-cell genomic analysis, we provide a resource mapping cell states and types during gastruloid development ...

CELL PRESS2023

Sequential and directional insulation by conserved CTCF sites underlies the Hox timer in stembryos

Denis Duboule, Alexandre Gauthier Aurèle Mayran, Hocine Rekaik, Célia Corinne Renée Bochaton, Lucille Delisle, Aurélie Hintermann

Temporal activation of Hox genes in mouse pseudo-embryos in vitro initiates at the anterior part of the cluster and is accompanied by asymmetric loading of cohesin. Posterior CTCF sites then successively act as transient insulators, regulating the timed tr ...

NATURE PORTFOLIO2023

Transgenic Model Systems Have Revolutionized the Study of Disease

Alexandre Gauthier Aurèle Mayran, Christopher Chase Bolt

The current pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected most of the world in a profound way. As an indirect consequence, the general public has been put into direct contact with the research process, almost ...

MARY ANN LIEBERT, INC2021

HOX13-dependent chromatin accessibility underlies the transition towards the digit development program

Alexandre Gauthier Aurèle Mayran

Hox genes encode transcription factors (TFs) that establish morphological diversity in the developing embryo. The similar DNA-binding motifs of the various HOX TFs contrast with the wide-range of HOX-dependent genetic programs. The influence of the chromat ...

Nature Research2020