Publications de Amaia Martinez Usatorre

CYTOKINE-ARMORED DENDRITIC CELL PROGENITORS SYNERGIZE WITH CAR-T CELLS IN SOLID TUMORS

Michele De Palma, Ali Ghasemi, Amaia Martinez Usatorre

Mary Ann Liebert, Inc2023

Engineered progenitor cells and methods of use

Michele De Palma, Ali Ghasemi, Amaia Martinez Usatorre

Disclosed herein are engineered progenitor cells and methods of using the same. Also disclosed herein are engineered cells differentiated from engineered progenitor cells of the present disclosure. Also disclosed herein are methods of treating a condition ...

2023

Dendritic cell cross-dressing and tumor immunity

Michele De Palma, Amaia Martinez Usatorre

In addition to direct and cross-presentation, dendritic cells (DCs) can present tumor antigens (TAs) to T cells via a hitherto poorly understood mechanism called "cross-dressing." DC cross-dressing involves the acquisition of preformed peptide-major histoc ...

WILEY2022

Determinants of tumor resistance to anti-angiogenic immunotherapy in mouse models of Kras-mutant NSCLC

Michele De Palma, Bruno Torchia, Etienne Meylan, Chiara Cianciaruso, Sina Nassiri, Ioanna Keklikoglou, Ece Kadioglu, Amaia Martinez Usatorre, Alan Nicolas Thierry Guichard

AMER ASSOC CANCER RESEARCH2021

Gain of HIF1 Activity and Loss of miRNA let-7d Promote Breast Cancer Metastasis to the Brain via the PDGF/PDGFR Axis

Amaia Martinez Usatorre

Early detection and adjuvant therapies have significantly improved survival of patients with breast cancer over the past three decades. In contrast, management of metastatic disease remains unresolved. Brain metastasis is a late complication frequently obs ...

AMER ASSOC CANCER RESEARCH2021

Alzheimer's drug turns macrophages against cancer

Michele De Palma, Amaia Martinez Usatorre

NATURE PORTFOLIO2021

Overcoming microenvironmental resistance to PD-1 blockade in genetically engineered lung cancer models

Michele De Palma, Nadine Fournier, Bruno Torchia, Etienne Meylan, Chiara Cianciaruso, Sina Nassiri, Ioanna Keklikoglou, Ece Kadioglu, Gael Luis Boivin, Amaia Martinez Usatorre

Immune checkpoint blockade (ICB) with PD-1 or PD-L1 antibodies has been approved for the treatment of nonsmall cell lung cancer (NSCLC). However, only a minority of patients respond, and sustained remissions are rare. Both chemotherapy and antiangiogenic d ...

AMER ASSOC ADVANCEMENT SCIENCE2021

A LIGHTning Strike to the Metastatic Niche

Michele De Palma, Amaia Martinez Usatorre

Tumor-induced vascular alterations in distant organs have been linked to the spreading of cancer. In this issue of Cell Reports, He et al. (2019) show that targeting the cytokine LIGHT to the pulmonary vasculature prevents the establishment of lung metasta ...

2020

Mechanisms Of Lung Cancer Hyper-Progression Promoted By Pd-1 Immune Checkpoint Blockade

Etienne Meylan, Julien Robert Rémi Faget, Amaia Martinez Usatorre

BMJ PUBLISHING GROUP2020

Enhanced Phenotype Definition for Precision Isolation of Precursor Exhausted Tumor-Infiltrating CD8 T Cells

Pedro Romero, Amaia Martinez Usatorre

In the context of adoptive T cell transfer (ACT) for cancer treatment, it is crucial to generate in vitro large amounts of tumor-specific CD8 T cells with high potential to persist in vivo. PD-1, Tim3, and CD39 have been proposed as markers of tumor-specif ...

2020