Publications de Andrea Agnoletto

biogrowleR: Enhancing Longitudinal Data Analysis

Cathrin Brisken, Giovanna Ambrosini, Hazel Margaret Quinn, Carlos Henrique Venturi Ronchi, Andrea Agnoletto

Time course measurements are used for many applications in biomedical research, ranging from growth curves to drug efficacy testing and high-throughput screening. Statistical methods used to analyze the resulting longitudinal data, such as t-tests or repea ...

Springer Science and Business Media LLC2025

Hormone Signaling in Breast Development and Cancer

Cathrin Brisken, Andrea Agnoletto

Hormones control normal breast development and function. They also impinge on breast cancer (BC) development and disease progression in direct and indirect ways. The major ovarian hormones, estrogens and progesterone, have long been established as key regu ...

2025

Androgen Receptor Signaling in in vivo models of Estrogen Receptor-positive Breast Cancer and Normal Breast Epithelium

Andrea Agnoletto

Steroid hormone receptors (HRs) are ligand-activated transcription factors that play a pivotal role in breast development and carcinogenesis. It is well established that estrogen receptor (ER) signaling is a major proliferative driver in estrogen receptor ...

EPFL2024

TGF beta-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression

Cathrin Brisken, Andrea Agnoletto

Ductal carcinoma in situ (DCIS) is a non-obligate precursor of invasive breast cancer. Virtually all women with DCIS are treated, despite evidence suggesting up to half would remain with stable, non-threatening, disease. Overtreatment thus presents a press ...

NATURE PORTFOLIO2023

Epigenetic silencing of selected hypothalamic neuropeptides in narcolepsy with cataplexy

Christian Iseli, Andrea Agnoletto

Narcolepsy with cataplexy is a sleep disorder caused by deficiency in the hypothalamic neuropeptide hypocretin/orexin (HCRT), unanimously believed to result from autoimmune destruction of hypocretin-producing neurons. HCRT deficiency can also occur in seco ...

National Academy of Sciences2023

Estrogen receptor positive breast cancers have patient specific hormone sensitivities and rely on progesterone receptor

Cathrin Brisken, Giovanna Ambrosini, Ayyakkannu Ayyanan, Laura Battista, Valentina Scabia, Fabio De Martino, Csaba Ferenc László, Andrea Agnoletto

Estrogen and progesterone receptor (ER, PR) signaling control breast development and impinge on breast carcinogenesis. ER is an established driver of ER + disease but the role of the PR, itself an ER target gene, is debated. We assess the issue in clinical ...

Nature Portfolio2022