Publications de Marco Julian Kühn

Antagonistic response regulators spatially regulate receptor methylation in the Pseudomonas aeruginosa Pil-Chp surface sensing system

Alexandre Louis André Persat, Marco Julian Kühn

Most bacterial chemosensory systems encode enzymes that are predicted to methylate and demethylate their chemoreceptors to control signaling activity. Here, we show that a predicted methyltransferase (PilK) and methylesterase (ChpB) methylate and demethyla ...

2025

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Xavier Jean-Yves Pierrat, Joanne Netter Engel, Marco Julian Kühn

The opportunistic pathogen Pseudomonas aeruginosa adapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface-specific twitching motility, allow single cells to sense surfaces and contro ...

WILEY2023

Polar flagellar wrapping and lateral flagella jointly contribute to Shewanella putrefaciens environmental spreading

Marco Julian Kühn

Flagella enable bacteria to actively spread within the environment. A number of species possess two separate flagellar systems, where in most cases a primary polar flagellar system is supported by distinct secondary lateral flagella under appropriate condi ...

2022

Wrapped Up: The Motility of Polarly Flagellated Bacteria

Marco Julian Kühn

A huge number of bacterial species are motile by flagella, which allow them to actively move toward favorable environments and away from hazardous areas and to conquer new habitats. The general perception of flagellum-mediated movement and chemotaxis is do ...

2022

Roadmap on emerging concepts in the physical biology of bacterial biofilms: from surface sensing to community formation

Alexandre Louis André Persat, Marco Julian Kühn

Bacterial biofilms are communities of bacteria that exist as aggregates that can adhere to surfaces or be free-standing. This complex, social mode of cellular organization is fundamental to the physiology of microbes and often exhibits surprising behavior. ...

IOP PUBLISHING LTD2021

Mechanotaxis directs Pseudomonas aeruginosa twitching motility

Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Xavier Jean-Yves Pierrat, Jose Negrete Jr, Marco Julian Kühn, Joanne Netter Engel

The opportunistic pathogen Pseudomonas aeruginosa explores surfaces using twitching motility powered by retractile extracellu-lar filaments called type IV pili (T4P). Single cells twitch by sequen-tial T4P extension, attachment, and retraction. How single ...

National Academy of Sciences2021