Publications de Luis Francisco Lorenzo Martin

Spatiotemporal Interrogation of Single Spheroids Using Multiplexed Nanoplasmonic-fluorescence Imaging

Hatice Altug, Matthias Lütolf, Yen-Cheng Liu, Saeid Ansaryan, Luis Francisco Lorenzo Martin

Advances in organoid models, as ex vivo mini-organs, and the development of screening imaging technologies have continuously driven each other forward. A complete understanding of organoids requires detailed insights into the intertwined intraorganoid and ...

WILEY-V C H VERLAG GMBH2025

Active R-RAS2/TC21 prevents cell cycle arrest and morphological alterations in mouse embryonic fibroblasts lacking RAS proteins

Luis Francisco Lorenzo Martin

R-RAS2/TC21, a member of the R-RAS subfamily of GTP-binding proteins, shares structural and signaling properties with the RAS subfamily proteins H-, K-, and N-RAS. However, little information is available regarding its role in normal cells and the level of ...

2025

Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts

Luis Francisco Lorenzo Martin

Background: Sos1 and Sos2 are guanine-nucleotide exchange factors for Ras and Rac small GTPases, which are involved in a wide range of cellular responses including proliferation and migration. We have previously shown that Sos1 and Sos2 have different effe ...

2025

Mini-colons unlock tumour development outside the body

Matthias Lütolf, Luis Francisco Lorenzo Martin

In this Tools of the Trade article, Francisco Lorenzo-Mart & iacute;n and Matthias Lutolf present mini-colons as a new ex vivo cancer model that incorporates microfabrication, tissue engineering and optogenetics. ...

Nature Portfolio2024

VAV2 orchestrates the interplay between regenerative proliferation and ribogenesis in both keratinocytes and oral squamous cell carcinoma

Luis Francisco Lorenzo Martin

VAV2 is an activator of RHO GTPases that promotes and maintains regenerative proliferation-like states in normal keratinocytes and oral squamous cell carcinoma (OSCC) cells. Here, we demonstrate that VAV2 also regulates ribosome biogenesis in those cells, ...

Nature Research2024

RNA Expression of MMP12 Is Strongly Associated with Inflammatory Bowel Disease and Is Regulated by Metabolic Pathways in RAW 264.7 Macrophages

Luis Francisco Lorenzo Martin

Macrophage metalloelastase or matrix metalloproteinase-12 (MMP12) is a macrophage-specific proteolytic enzyme involved in the physiopathology of many inflammatory diseases, including inflammatory bowel disease. Although previously published data suggested ...

MDPI2024

Next-generation patient models for colorectal cancer research

Matthias Lütolf, Luis Francisco Lorenzo Martin

Lab-grown 'mini-colons' enable the simulation of colorectal tumor dynamics and the high-resolution study of interactions with cells from the tumor's native microenvironment. These next-generation organoids offer a wealth of new experimental opportunities, ...

NATURE PORTFOLIO2024

Spatiotemporally resolved colorectal oncogenesis in mini-colons ex vivo

Freddy Radtke, Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Tania Hübscher, Luis Francisco Lorenzo Martin, Amber Dawn Bowler

Three-dimensional organoid culture technologies have revolutionized cancer research by allowing for more realistic and scalable reproductions of both tumour and microenvironmental structures 1-3 . This has enabled better modelling of low-complexity cancer ...

NATURE PORTFOLIO2024

Nanoplasmonic Single-Tumoroid Microarray for Real-Time Secretion Analysis

Hatice Altug, Nicolas Antoine Vincent Broguiere, Yen-Cheng Liu, Saeid Ansaryan, Luis Francisco Lorenzo Martin

Organoid tumor models have emerged as a powerful tool in the fields of biology and medicine as such 3D structures grown from tumor cells recapitulate better tumor characteristics, making these tumoroids unique for personalized cancer research. Assessment o ...

2024