The invention provides microfluidic screening systems for the identification of compounds or compositions influencing cellular transcriptomes. The invention is predicated upon taking into account differences in newly synthesized mRNA in contrast to so call ...
Here, we present Link-Seq, a highly efficient droplet microfluidic method for combined sequencing of antibody-encoding genes and the transcriptome of individual B cells at large scale. The method is based on 3 ' barcoding of the transcriptome and subsequen ...
The discovery of new therapeutic antibodies plays a crucial role in modern medicine, with monoclonal antibodies representing the majority of the 10 best-selling drugs in the world today. These antibodies are used to treat various diseases, including infect ...
Engineering and computational advances have opened many new avenues in cancer research, particularly when being exploited in interdisciplinary approaches. For example, the combination of microfluidics, novel sequencing technologies, and computational analy ...
