Publications de Mats Julius Stensrud

A positivity robust strategy to study effects of switching treatment

In studies of medical treatments, individuals often experience post-treatment events that predict their future outcomes. In this work, we study how to use initial observations of a recurrent event - a type of post-treatment event - to offer updated treatme ...

2025

The Authors Respond

Mats Julius Stensrud

2025

Improved bounds and inference on optimal regimes

Mats Julius Stensrud, Aaron Leor Sarvet

Point identification of causal effects requires strong assumptions that are unreasonable in many practical settings. However, bounds on these effects can often be derived under plausible assumptions. Even when these bounds are wide or cover null effects, t ...

Informa UK Limited2025

Explaining the sharp decline in birth rates in Canada and the United States in 2020

Mats Julius Stensrud

Birth rates in Canada and the United States declined sharply in March 2020 and deviated from historical trends. This decline was absent in similarly developed European countries. We argue that the selective decline was driven by incoming individuals, who w ...

OXFORD UNIV PRESS INC2025

Perspectives on "harm" in personalized medicine

Mats Julius Stensrud

Avoiding harm is an uncontroversial aim of personalized medicine and other epidemiologic initiatives. However, the precise mathematical translation of "harm"is disputable. Here, we use a formal causal language to study common, but distinct, definitions of ...

Oxford University Press (OUP)2025

Explaining the Relationships Between Age, Endocrine Therapy Persistence, and Risk of Recurrence in Hormone Receptor–Positive Early Breast Cancer: A Nationwide Cohort Study

Mats Julius Stensrud, Elise Hélène Dumas

Young age is associated with increased risk of recurrence in hormone receptor (HR)–positive early-stage breast cancer (eBC). Lack of adherence to endocrine therapy (ET) is a potential reason for the lower survival proportions observed in younger patients, ...

American Society of Clinical Oncology (ASCO)2025

Variant Specific Treatment Effects with Applications in Vaccine Studies

Mats Julius Stensrud

Pathogens usually exist in heterogeneous variants, like subtypes and strains. Quantifying treatment effects on the different variants is important for guiding prevention policies and vaccine development. Here, we ground analyses of variant-specific effects ...

OXFORD UNIV PRESS2025

Immune-selection stability is a neglected property of the causal risk ratio

Mats Julius Stensrud

Risk ratios are one of the most commonly used effect measures in epidemiology. Yet their properties and transportability across different populations remain debated. In this article, we show that the causal risk ratio is stable to selection based on immune ...

Oxford University Press (OUP)2025

How hazard ratios can mislead and why it matters in practice

Mats Julius Stensrud, Elise Hélène Dumas

Hazard ratios are routinely reported as effect measures in clinical trials and observational studies. However, many methodological works have raised concerns about the interpretation of hazard ratios as causal effects. These concerns are often related to t ...

Springer Science and Business Media LLC2025

Why use methods that require proportional hazards?

Mats Julius Stensrud

We recently questioned the utility of testing for proportional hazards in survival analysis. Here, we expand on why the proportional hazards assumption is both implausible and unnecessary in most medical studies, particularly in randomized trials. We concl ...

OXFORD UNIV PRESS INC2025