Publications de Alexander Woglar

Mechanisms of axoneme and centriole elimination in Naegleria gruberi

Pierre Gönczy, Graham Knott, Coralie Busso, Gabriela Garcia Rodriguez, Alexander Woglar, Mary-Claude Croisier-Coeytaux

The early branching eukaryote Naegleria gruberi can transform transiently from an amoeboid life form lacking centrioles and flagella to a flagellate life form where these elements are present, followed by reversion to the amoeboid state. The mechanisms imp ...

SPRINGERNATURE2024

Disparate roles for C. elegans DNA translocase paralogs RAD-54.L and RAD-54.B in meiotic prophase germ cells

Alexander Woglar

RAD54 family DNA translocases partner with RAD51 recombinases to ensure stable genome inheritance, exhibiting biochemical activities both in promoting recombinase removal and in stabilizing recombinase association with DNA. Understanding how such disparate ...

OXFORD UNIV PRESS2023

Centriole elimination during Caenorhabditis elegans oogenesis initiates with loss of the central tube protein SAS-1

Pierre Gönczy, Coralie Busso, Alexander Woglar, Mary-Claude Croisier-Coeytaux, Tamara Mikeladze-Dvali, Keshav Jha, Marie Juliette Ségolène Pierron

In most metazoans, centrioles are lost during oogenesis, ensuring that the zygote is endowed with the correct number of two centrioles, which are paternally contributed. How centriole architecture is dismantled during oogenesis is not understood. Here, we ...

Wiley2023

Molecular architecture of the C. elegans centriole

Pierre Gönczy, Coralie Busso, Alexander Woglar, Keshav Jha, Marie Juliette Ségolène Pierron, Fabian Zacharias Schneider

Uncovering organizing principles of organelle assembly is a fundamental pursuit in the life sciences. Caenorhabditis elegans was key in identifying evolutionary conserved components governing assembly of the centriole organelle. However, localizing these c ...

2022

Atypical and distinct microtubule radial symmetries in the centriole and the axoneme of Lecudina tuzetae

Pierre Gönczy, Coralie Busso, Alexandra Bezler, Alexander Woglar, Fabian Zacharias Schneider

The centriole is a minute cylindrical organelle present in a wide range of eukaryotic species. Most centrioles have a signature ninefold radial symmetry of microtubules that is imparted to the axonemes of the cilia and flagella they template, with nine cen ...

AMER SOC CELL BIOLOGY2022

Robust designation of meiotic crossover sites by CDK-2 through phosphorylation of the MutS gamma complex

Alexander Woglar

Crossover formation is essential for proper segregation of homologous chromosomes during meiosis. Here, we show that Caenorhabditis elegans cyclin-dependent kinase 2 (CDK-2) partners with cyclin-like protein COSA-1 to promote crossover formation by promoti ...

National Academy of Sciences2022