Publications de Qi Wang | EPFL Graph Search

A lysosomal surveillance response to stress extends healthspan

Johan Auwerx, Xiaoxu Li, Tanes Imamura de Lima, Jia Liu, Qi Wang, Wen Gao, Yang Li, Amélia Lalou

Lysosomes are cytoplasmic organelles central for the degradation of macromolecules to maintain cellular homoeostasis and health. However, how lysosomal activity can be boosted to counteract ageing and ageing-related diseases remains elusive. Here we reveal ...

Springer Science and Business Media LLC2025

ACMSD inhibition corrects fibrosis, inflammation, and DNA damage in MASLD/MASH

Johan Auwerx, Xiaoxu Li, Jia Liu, Qi Wang, Sandra Rodriguez Lopez, Keno Strotjohann

Background & Aims: Recent findings reveal the importance of tryptophan-initiated de novo nicotinamide adenine dinucleotide (NAD+) synthesis in the liver, a process previously considered secondary to biosynthesis from nicotinamide. The enzyme α-amino-β-carb ...

2025

The 2024 Magnonics Roadmap

Dirk Grundler, Thomas Yu, Ping Che, Qi Wang, Wei Zhang, Benedetta Flebus

Magnonics is a research field that has gained an increasing interest in both the fundamental and applied sciences in recent years. This field aims to explore and functionalize collective spin excitations in magnetically ordered materials for modern informa ...

2024

Cyclo(His-Pro): A further step in the management of steatohepatitis

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Alessia De Masi

Background & Aims: Non-alcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH) have become the world's most common liver diseases, placing a growing strain on healthcare systems worldwide. Nonetheless, no effective pharmacological treatment has be ...

ELSEVIER2023

Lysosomes mediate the mitochondrial UPR via mTORC1-dependent ATF4 phosphorylation

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Wen Gao, Yang Li

Lysosomes are central platforms for not only the degradation of macromolecules but also the integration of multiple signaling pathways. However, whether and how lysosomes mediate the mitochondrial stress response (MSR) remain largely unknown. Here, we demo ...

SPRINGERNATURE2023

Cyclo (His-Pro) Prevents Diet-Induced Fatty Liver Disease

Johan Auwerx, Xiaoxu Li, Qi Wang, Adrienne Joëlle Laurence Mottis, Alexis Rapin, Alessia De Masi

WILEY2022

Sphingolipids accumulate in aged muscle, and their reduction counteracts sarcopenia

Johan Auwerx, Davide D'Amico, Tanes Imamura de Lima, Qi Wang, Sébastien Robert Victor Herzig, Maroun Bou Sleiman, Martin Rainer Wohlwend, Peiling Luan, Pirkka-Pekka Untamo Laurila, Barbara Moreira Crisol

Age-related muscle dysfunction and sarcopenia are major causes of physical incapacitation in older adults and currently lack viable treatment strategies. Here we find that sphingolipids accumulate in mouse skeletal muscle upon aging and that both genetic a ...

2022

TGR5/Cathepsin E signaling regulates macrophage innate immune activation in liver ischemia and reperfusion injury

Johan Auwerx, Kristina Schoonjans, Qi Wang

The role and underlying mechanism of plasma membrane-bound G protein-coupled bile acid receptor (TGR5) in regulating macrophage innate immune activation during liver ischemia and reperfusion (IR) injury remains largely unclear. Here, we demonstrated that T ...

2021

Battle of the Water Networks II

José Pedro Gamito de Saldanha Calado Matos, Qi Wang, Marco Franchini

The Battle of the Water Networks II (BWN-II) is the latest of a series of competitions related to the design and operation of water distribution systems (WDSs) undertaken within the Water Distribution Systems Analysis (WDSA) Symposium series. The BWN-II pr ...

American Society of Civil Engineers2014