Personne
Chao Fan
Publications associées (4)
Regiodivergent and Enantioselective Synthesis of Cyclic Sulfones via Ligand-Controlled Nickel-Catalyzed Hydroalkylation
Cyclic sulfones have demonstrated important applications in drug discovery. However, the catalytic and enantioselective synthesis of chiral cyclic sulfones remains challenging. Herein, we develop nickel-catalyzed regiodivergent and enantioselective hydroal ...
Wiley-V C H Verlag Gmbh2024Streamlined Alkylation via Nickel-Hydride-Catalyzed Hydrocarbonation of Alkenes
Xile Hu, Chao Fan, Srikrishna Bera, Zhikun Zhang
Compounds rich in sp(3)-hybridized carbons are desirable in drug discovery. Nickel-catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these compounds. By using abundant, readily available, and stable alkenes as pro-nucleo ...
AMER CHEMICAL SOC2022Enantio- and diastereoselective construction of vicinal C(sp(3)) centres via nickel-catalysed hydroalkylation of alkenes
Xile Hu, Chao Fan, Srikrishna Bera
In drug discovery, the proportion of aliphatic carbons (C(sp(3))) and the presence of chiral carbons in organic molecules are positively correlated to their chance of clinical success. Although methods exist for the synthesis of chiral C(sp(3))-rich molecu ...
NATURE PORTFOLIO2022