Publications de Benjamin Joao Clément Antonin Hadrien Martin

An out-of-equilibrium definition of protein turnover

David Michael Suter, Benjamin Joao Clément Antonin Hadrien Martin

Protein turnover (PT) has been formally defined only in equilibrium conditions, which is ill-suited to quantify PT during dynamic processes that occur during embryogenesis or (extra) cellular signaling. In this Hypothesis, we propose a definition of PT in ...

2023

Exploring the role of transcriptional and post-transcriptional processes in mRNA co-expression

Benjamin Joao Clément Antonin Hadrien Martin

Co-expression of two or more genes at the single-cell level is usually associated with functional co-regulation. While mRNA co-expression-measured as the correlation in mRNA levels-can be influenced by both transcriptional and post-transcriptional events, ...

Wiley2023

Gene expression flux analysis reveals specific regulatory modalities of gene expression

David Michael Suter, Benjamin Joao Clément Antonin Hadrien Martin

The level of a given protein is determined by the synthesis and degradation rates of its mRNA and protein. While several studies have quantified the contribution of different gene expression steps in regulating protein levels, these are limited by using eq ...

2023

Molecular basis of Arginine and Lysine DNA sequence-dependent thermo-stability modulation

Benjamin Joao Clément Antonin Hadrien Martin

We have used a variety of theoretical and experimental techniques to study the role of four basic amino acids-Arginine, Lysine, Ornithine and L-2,4-Diaminobutyric acid-on the structure, flexibility and sequence-dependent stability of DNA. We found that the ...

2022