Publications de Meltem Tatli | EPFL Graph Search

Arrestin recognizes GPCRs independently of the receptor state

Henning Paul-Julius Stahlberg, Dongchun Ni, Meltem Tatli

Only two nonvisual arrestins recognize many hundreds of different, intracellularly phosphorylated G protein-coupled receptors (GPCRs). Due to the highly dynamic nature of GPCR•arrestin complexes, the critical determinants of GPCR–arrestin recognition have ...

Proceedings of the National Academy of Sciences2025

Author Correction: Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

Henning Paul-Julius Stahlberg, Hilal Lashuel, Sergey Nazarov, Meltem Tatli, Galina Limorenko, Rajasekhar Kolla

Nature Research2024

Hierarchical Protofilament Intertwining Rules the Formation of Mixed‐Curvature Amyloid Polymorphs

Giovanni Dietler, Henning Paul-Julius Stahlberg, Serguei Sekatski, Meltem Tatli, Francesco Simone Ruggeri, Jiangtao Zhou

Amyloid polymorphism is a hallmark of almost all amyloid species, yet the mechanisms underlying the formation of amyloid polymorphs and their complex architectures remain elusive. Commonly, two main mesoscopic topologies are found in amyloid polymorphs cha ...

Wiley2024

Fully co-factor-free ClearTau platform produces seeding-competent Tau fibrils for reconstructing pathological Tau aggregates

Henning Paul-Julius Stahlberg, Hilal Lashuel, Meltem Tatli, Galina Limorenko, Rajasekhar Kolla

The authors report a method for producing co-factor-free fibrils from all full-length Tau isoforms. The method paves the way for reconstituting pathology resembling Tau fibrils and enables screening of Tau aggregation-modifying compounds for targeted thera ...

Nature Research2023