Glial cell line-derived neurotrophic factor released by synthetic guidance channels promotes facial nerve regeneration in the rat
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We have fabricated a soft silicone structure to support the regeneration of a sciatic nerve. The device consists of 70 parallel (120 x 110 mu m(2)) channels through which axons extend and then reconnect to the muscles on the other side of the device. Throu ...
The present work was performed to determine the ability of neurotrophic factors to allow axonal regeneration across a 15-mm-long gap in the rat sciatic nerve. Synthetic nerve guidance channels slowly releasing NGF and GDNF were fabricated and sutured to th ...
To date, delivery of neurotrophic factors has only allowed to transiently protect axotomized facial motoneurons against cell death. In the present report, long-term protection of these neurons was evaluated by continuously expressing the neurotrophic facto ...
