Publication
Notch1 and Notch2 receptors influence progressive hair graying in a dose-dependent manner
Publications associées (48)
Tp63-expressing adult epithelial stem cells cross lineages boundaries revealing latent hairy skin competence
Yann Barrandon, Ariane Rochat, Stéphanie Claudinot, Paola Bonfanti, Daniel-Alexandre Littman, Christèle Gonneau
The formation of hair follicles, a landmark of mammals, requires complex mesenchymal-epithelial interactions and it is commonly believed that embryonic epidermal cells are the only cells that can respond to hair follicle morphogenetic signals in vivo. Here ...
NATURE RESEARCH2020Selective Peptide-Mediated Enhanced Deposition of Polymer Fragrance Delivery Systems on Human Hair
Harm-Anton Klok, Kemal Arda Günay
The deposition of fragrance delivery systems onto human hair from a shampoo formulation is a challenging task, as the primary function of shampoo is to cleanse the hair by removing primarily hydrophobic moieties. In this work, to tackle this challenge, pha ...
2017Single-Cell Transcriptomics Reveals that Differentiation and Spatial Signatures Shape Epidermal and Hair Follicle Heterogeneity
The murine epidermis with its hair follicles represents an invaluable model system for tissue regeneration and stem cell research. Here we used single-cell RNA-sequencing to reveal how cellular heterogeneity of murine telogen epidermis is tuned at the tran ...
2016Bioinspired Selective Surface Deposition of Fragrance Delivery Systems
The perception of pleasantness in many of the consumer goods is provided by volatile chemical compounds called fragrances. While the volatility of fragrances is essential to provide a pleasant olfactory response, it presents at the same time a technologi ...
EPFL2016HOXA5 Counteracts Stem Cell Traits by Inhibiting Wnt Signaling in Colorectal Cancer
Paloma Ordonez Moran, Caroline Dafflon
Hierarchical organization of tissues relies on stem cells, which either self-renew or produce committed progenitors predestined for lineage differentiation. Here we identify HOXA5 as an important repressor of intestinal stem cell fate in vivo and identify ...
Elsevier2015The Notch pathway controls fibrotic and regenerative repair in the adult heart
Freddy Radtke, Mario Gaetano Lepore
Aims In the adult heart, Notch signalling regulates the response to injury. Notch inhibition leads to increased cardiomyocyte apoptosis, and exacerbates the development of cardiac hypertrophy and fibrosis. The role of Notch in the mesenchymal stromal cell ...
Oxford University Press2014Stem cells living with a Notch
Freddy Radtke, Ute Koch, Rajwinder Lehal
Notch signaling has been shown over the past few decades to play fundamental roles in a plethora of developmental processes in an evolutionarily conserved fashion. Notch-mediated cell-to-cell signaling is involved in many aspects of embryonic development a ...
Company of Biologists2013Temperature impacts human epidermal stem cell behaviour through thermoTRPs and mTOR signalling
Adult stem cells are characterized by their unique ability to self-renew and give rise to a progeny of specialized/differentiated cells. Therefore, they have a remarkable potential for regenerative medicine. However, the use of adult stem cells is restrain ...
EPFL2013Notch Signaling in Pigment Cells and Generation of Mouse Models for Ocular Diseases
Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival and differentiation. In melanocytes, Notch signaling is essential for the maintenance of melanocytes and the melanocyte stem cell population. Whereas, ...
EPFL2013Jagged1 is the major regulator of notch-dependent cell fate in proximal airways
Background: The Notch signaling pathway plays complex roles in developing lungs, including regulation of proximodistal fates, airway cell specification and differentiation. However, the specific Notch-mediated signals involved in lung development remain un ...
Wiley-Blackwell2013