Mathematical and numerical models for transfer of low-density lipoproteins through the arterial walls: A new methodology for the model set up with applications to the study of disturbed lumenal flow
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Most cells acquire cholesterol by endocytosis of circulating low-density lipoproteins (LDLs). After cholesteryl ester de-esterification in endosomes, free cholesterol is redistributed to intracellular membranes via unclear mechanisms. Our previous work sug ...
Cardiotrophin-1 (CT-1) is associated with cardiovascular (CV) diseases. We investigated the effect of CT-1 deficiency in the development and progression of atherosclerosis in double knockout Apoe(-/-)ct-1(-/-) mice. Apoe(-/-) C57Bl/6 or Apoe(-/-)ct-1(-/-) ...
In this thesis we explore uncertainty quantification of forward and inverse problems involving differential equations. Differential equations are widely employed for modeling natural and social phenomena, with applications in engineering, chemistry, meteor ...
The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, we applied the pharmacological Sirt1 activator SRT3025 in a mouse model of athe ...
This paper is devoted to the mathematical modelling and numerical simulation of basic mechanisms that drive multicontinuum systems in two- and three-dimensional porous media. We state a general mathematical model within the framework of mixture theory, cap ...
The cholesteryl ester transfer protein (CETP) enables the transfer of cholesteryl ester (CE) from high density lipoproteins (HDL) to low-density lipoproteins (LDL) in the plasma compartment. CETP inhibition raises plasma levels of HDL cholesterol; a ternar ...
Postprandial inflammation is an important factor for human health since chronic low-grade inflammation is associated with chronic diseases. Dairy products have a weak but significant anti-inflammatory effect on postprandial inflammation. The objective of t ...
Reverse cholesterol transport (RCT) refers to the mobilization of cholesterol on HDL particles (HDL-C) from extravascular tissues to plasma, ultimately for fecal excretion. Little is known about how HDL-C leaves peripheral tissues to reach plasma. We first ...
In this work, two problems linked to glacier modeling are investigated. We propose an optimisation method for studying the flow of the ice and we present a numerical study about glacier thermal phenomena. In the first chapter of this thesis, we expose the ...
The purpose of this thesis is the study, from the numerical simulation point of view, of the aluminum electrolysis process. Navier-Stokes equations for the computation of a two fluids flow with free interface are coupled with Maxwell equations describing t ...