Involvement of residues 296-299 in the enzymatic activity of tissue-type plasminogen activator
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Site directed mutagenesis was used to construct a t-PA variant that contains an additional glycosylation site in the first kringle domain (T103N) combined with a tetra-alanine substitution in the protease domain (KHRR 296-299 AAAA). This combination varian ...
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