Publication
The tyrosinase enhancer is activated by Sox10 and Mitf in mouse melanocytes
Publications associées (35)
Context-dependent enhancer function revealed by targeted inter-TAD relocation
Denis Duboule, Lucille Delisle, Guillaume Andrey, Christopher Chase Bolt, Aurélie Hintermann
Here the authors show that a strong enhancer sequence can be controlled by the chromatin environment provided by a topologically associated domain (TAD) located nearby. An enhancer relocated by homologous recombination takes all the hallmarks of its new ne ...
NATURE PORTFOLIO2022A complex regulatory landscape involved in the development of mammalian external genitals
Denis Duboule, Lucille Delisle, Christopher Chase Bolt
Developmental genes are often controlled by large regulatory landscapes matching topologically associating domains (TADs). In various contexts, the associated chromatin backbone is modified by specific enhancer-enhancer and enhancer-promoter interactions. ...
2020A General Framework for Pearlescent Materials
Wenzel Alban Jakob, Ibon Guillen Serrano
The unique and visually mesmerizing appearance of pearlescent materials has made them an indispensable ingredient in a diverse array of applications including packaging, ceramics, printing, and cosmetics. In contrast to their natural counterparts, such syn ...
ASSOC COMPUTING MACHINERY2020Mechanistic insights into AMP-activated protein kinase-dependent gene expression
AMP-activated protein kinase (AMPK) is a fundamental enzyme that controls energy homeostasis, through orchestrating the cellular response to a reduction in energy availability. Under conditions of cellular energy stress AMPK senses the decrease in ATP leve ...
EPFL2019Rhythmic and clock-dependent chromatin loops regulate circadian gene expression
In mammals the circadian clock drives daily behavioural and physiological changes that resonate with environmental cues, which can be observed, for example, in the intricate timing of rest during the night and activity during the day in humans. The circadi ...
EPFL2017Functional Characterization of Nucleoid Associated Proteins Acting as Global Transcription Factors in Mycobacterium tuberculosis
The fatal lung disease tuberculosis is caused by the airborne Mycobacterium tuberculosis, a versatile pathogen adapted to rapidly changing environments. Instead of being eradicated by phagocytic cells of its human host, bacilli tune macrophages to support ...
EPFL2017Modeling of transcription mechanisms in mammals from kinetic measurements in single cells
In mammals, transcription was observed to occur predominantly in bursts, resulting from short and intense periods of gene transcription interspersed by longer silent periods. In order to elucidate the causes and the consequences of discontinuous transcript ...
EPFL2014Enhancer loops appear stable during development and are associated with paused polymerase
Developmental enhancers initiate transcription and are fundamental to our understanding of developmental networks, evolution and disease. Despite their importance, the properties governing enhancer-promoter interactions and their dynamics during embryogene ...
Nature Publishing Group2014Chromatin looping and organization at developmentally regulated gene loci
Denis Duboule, Daniël Noordermeer
Developmentally regulated genes are often controlled by distant enhancers, silencers and insulators, to implement their correct transcriptional programs. In recent years, the development of 3C and derived techniques (4C, 5C, HiC, ChIA- PET, etc.) has confi ...
2013Multiple Enhancers Regulate Hoxd Genes and the Hotdog LncRNA during Cecum Budding
Denis Duboule, Marion Leleu, Saskia Joëlle Delpretti Anex
Hox genes are required for the development of the intestinal cecum, a major organ of plant-eating species. We have analyzed the transcriptional regulation of Hoxd genes in cecal buds and show that they are controlled by a series of enhancers located in a g ...
Elsevier2013