Publication

Noncoding 3' sequences of the transferrin receptor gene are required for mRNA regulation by iron

Publications associées (38)

Iron sequestration by transferrin 1 mediates nutritional immunity in Drosophila melanogaster

Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko, Alice Marra, Jasquelin Peña

Iron sequestration is a recognized innate immune mechanism against invading pathogens mediated by iron-binding proteins called transferrins. Despite many studies on antimicrobial activity of transferrins in vitro, their specific in vivo functions are poorl ...

NATL ACAD SCIENCES2020

Iron regulatory proteins and their role in controlling iron metabolism

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and ...

Royal Soc Chemistry2015

Microcontaminant degradation in municipal wastewater treatment plant secondary effluent by EDDS assisted photo-Fenton at near-neutral pH: An experimental design approach

César Pulgarin, Stefanos Papoutsakis

This work aims to evaluate the applicability of EDDS (ethylenediamine-N,N'-disuccinic acid) as an iron chelating agent for photo-Fenton treatment of municipal wastewater spiked with organic contaminants at near-neutral pH. A series of laboratory scale expe ...

Elsevier2015

Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria

Liviu Vanoaica

Disease tolerance is a defense strategy that limits the fitness costs of infection irrespectively of pathogen burden. While restricting iron (Fe) availability to pathogens is perceived as a host defense strategy, the resulting tissue Fe overload can be cyt ...

Cell Press2012

Analysis of mice with conditional ferritin H deletion

Liviu Vanoaica

Iron is a transitional metal required by virtually all organisms as a dietary micromineral, indispensable for cellular survival and proliferation. The management of iron absorption and distribution in the organism and inside the cell must be tightly regula ...

EPFL2009

Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant

Lukas Kühn

Insects, like vertebrates, express iron regulatory proteins (IRPs) that may regulate proteins in cellular iron storage and energy metabolism. Two mRNAs, an unspliced form of ferritin H mRNA and succinate dehydrogenase subunit b (SDHb) mRNA, are known to co ...

2008

KP1019, a new redox-active anticancer agent - preclinical development and results of a clinical phase I study in tumor patients

Paul Joseph Dyson, Christian Hartinger, Michael Groessl

A review. The promising drug candidate indazolium trans-[tetrachlorobis(1H-indazole)ruthenate(III)] (KP1019) is the second Ru-based anticancer agent to enter clin. trials. In this review, which is an update of a paper from 2006, the exptl. evidence for the ...

2008

International Union of Pharmacology. LXI. Peroxisome proliferator-activated receptors.

Johan Auwerx, Walter Wahli, Liliane Michalik

The three peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors of the nuclear hormone receptor superfamily. They share a high degree of structural homology with all members of the superfamily, particularly in the D ...

2006

Chemistry and biology of Anachelin and derivatives

Iron is an essential nutrient for virtually all forms of life. To overcome its extreme insolubility, many microbes synthesize and excrete powerful iron-selective chelating agents, so-called siderophores. Anachelin H (A) was recently isolated from the cyano ...

ETH Zurich2005

In vivo investigation of estrogenic activity by fluorescence techniques

Hanna Jankevics

Hormone binding nuclear receptors are transcription factors that activate gene transcription by binding to specific DNA sequences in the gene promoter region and then recruiting the necessary coactivator proteins for transcriptional activation. The knowled ...

EPFL2004

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