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Modeling Hox gene regulation in digits: reverse collinearity and the molecular origin of thumbness

Publications associées (37)

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Changes in Hox genes' structure and function during the evolution of the squamate body plan

Denis Duboule

Hox genes are central to the specification of structures along the anterior-posterior body axis, and modifications in their expression have paralleled the emergence of diversity in vertebrate body plans. Here we describe the genomic organization of Hox clu ...

Nature Publishing Group2010

Homeobox genes d11-d13 and a13 control mouse autopod cortical bone and joint formation

Denis Duboule

The molecular mechanisms that govern bone and joint formation are complex, involving an integrated network of signaling pathways and gene regulators. We investigated the role of Hox genes, which are known to specify individual segments of the skeleton, in ...

American Society for Clinical Investigation2010

Collinear expression of 5′ Hoxd genes during mammalian limb development is required to properly determine digits number and identity. We recently proposed a two-step model to account for the underlying regulatory mechanism, which involves an initial loopin ...

Elsevier Science BV2009

Hox genes control many aspects of embryonic development in metazoans. Previous analyses of this gene family has revealed a surprising diversity in terms of gene number and organization between various animal species. In vertebrates, Hox genes are grouped i ...

Elsevier Science BV2009

Uncoupling time and space in the collinear regulation of Hox genes

Denis Duboule, Jozsef Zakany

During development of the vertebrate body axis, Hox genes are transcribed sequentially, in both time and space, following their relative positions within their genomic clusters. Analyses of animal genomes support the idea that Hox gene clustering is essent ...

2009

Atypical relaxation of structural constraints in Hox gene clusters of the green anole lizard

Denis Duboule

Hox genes control many aspects of embryonic development in metazoans. Previous analyses of this gene family revealed a surprising diversity in terms of gene number and organization between various animal species. In vertebrates, Hox genes are grouped into ...

2009

The Hox complex - an interview with Denis Duboule. Interviewed by Richardson, Michael K

Denis Duboule

Denis Duboule is one of the most influential and highly-cited scientists in developmental biology. Born in Geneva in 1955, he holds dual Swiss and French nationality. His undergraduate studies in biology at the University of Geneva included research on mou ...

2009

Temporal and spatial control of Hox gene expression is essential for correct patterning of many animals. In both Drosophila and vertebrates, Polycomb and Trithorax group complexes control the maintenance of Hox gene expression in appropriate domains. In ve ...

2009

Genomic regulatory blocks encompass multiple neighboring genes and maintain conserved synteny in vertebrates

Andrew Charles Oates

We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their develop ...

2007

Evolutionary conserved sequences are required for the insulation of the vertebrate Hoxd complex in neural cells

Denis Duboule

Transcriptional regulation of vertebrate Hox genes involves enhancer sequences located either inside or outside the gene clusters. In the mouse Hoxd complex, for example, series of contiguous genes are coordinately controlled by regulatory sequences locate ...

2002