Publication
SIN and the art of splitting the fission yeast cell
Publications associées (90)
Primary data for EPFL thesis "Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4"
Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...
EPFL Infoscience2023Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4
Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...
EPFL2023Centromere structure and function: lessons from Drosophila
The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its differences to u ...
Bethesda2023Metabolic regulation of cytokinesis in Schizosaccharomyces pombe
All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...
EPFL2022Principles of checkpoint override
Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...
EPFL2022Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8
Meiotic processes are potentially dangerous to genome stability and could be disastrous if activated in proliferative cells. Here we show that two key meiosis-defining proteins, the topoisomerase Spo11 (which forms double-strand breaks) and the meiotic coh ...
NATURE RESEARCH2021Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells
Pierre Gönczy, Georgios Hatzopoulos, Tatiana Favez
Background The Canadian prairie ecosystem presents a rich source of natural products from plants that are subjected to herbivory by grazing mammals. This type of ecological competition may contribute to the production of natural products of interest in cel ...
SPRINGER2021Wnt-controlled sphingolipids modulate Anthrax Toxin Receptor palmitoylation to regulate oriented mitosis in zebrafish
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami
Oriented cell division is a fundamental mechanism to control asymmetric stem cell division, neural tube elongation and body axis extension, among other processes. During zebrafish gastrulation, when the body axis extends, dorsal epiblast cells display divi ...
NATURE PUBLISHING GROUP2020Spatial control of nucleoporin condensation by fragile X-related proteins
Nucleoporins (Nups) build highly organized nuclear pore complexes (NPCs) at the nuclear envelope (NE). Several Nups assemble into a sieve-like hydrogel within the central channel of the NPCs. In the cytoplasm, the soluble Nups exist, but how their assembly ...
WILEY2020Multi-phosphorylation reaction and clustering tune Pom1 gradient mid-cell levels according to cell size
Suliana Manley, Anna Archetti, Lina Carlini, Charlotte Sophia Floderer, Thaïs Reichler
Protein concentration gradients pattern developing organisms and single cells. In Schizosaccharomyces pombe rod-shaped cells, Pom1 kinase forms gradients with maxima at cell poles. Pom1 controls the timing of mitotic entry by inhibiting Cdr2, which forms s ...
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