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A novel bis-hydroxymethyl-substituted DTTA chelator N¢-Bz-C4,4¢-(CH2OH)2-DTTA (1) and its DTPA analogue C4,4¢-(CH2OH)2-DTPA (2) were synthesized and characterized. A variable-temperature 1H NMR spectroscopy study of the solution dynamics of their diamagnet ...
Nuclear magnetic relaxation in the presence of paramagnetic centres has gained increasing interest in recent years partly due to its importance for contrast agents in magnetic resonance imaging. Rational design of new more efficient agents is possible as a ...
This Ph.D. work deals with the development of lanthanide-based bioprobes for biomedical analyses and imaging. For this purpose, two different approaches have been followed, one focusing on visible-emitting complexes, while the second addresses the sensitiz ...
In attempts to synthesize compds. contg. mixed lanthanide and transition metal oxide magnetic nanostructures, a new 3d-4f arsenate phase, Na3GdMn3O3(AsO4)3, was isolated using high-temp., molten-salt methods. The X-ray single-crystal structure anal. shows ...
Coordination assemblies formed by metal(II) dithiocarbamates M-II(R(2)dtc)2 (M = Zn, Cd, Hg, Mn, and Fe; R = Me, Et, iPr, nPr, and nBu) and nitrogen-containing ligands (L = DABCO, DMP, and HMTA) are shown to be sterically well consistent with the spherical ...
We present an effective solution for the problem of contrast enhancement in phase-contrast microangiography, with the specific objective of visualising small (< 8 A mu m) vessels in tumor-related microangiogenesis. Different hydrophilic and hydrophobic con ...
To study the physicochemical properties of the DTTA chelating moiety (H4DTTA = diethylenetriaminetetraacetic acid = N,N′-[iminobis(ethane-2,1-diyl)]bis[N-(carboxymethyl)glycine]), used in several compounds proposed as magnetic resonance imaging (MRI) contr ...
The knowledge and understanding of the mechanism as well as the rate constant of the solvent exchange reactions are fundamental, since these reactions represent an important step in complex formation reactions on metal ions. Solvent exchange reactions in a ...
Three novel GdDO3A-type bismacrocyclic complexes, conjugated to Ca2+ chelating moieties like ethylenediamine-tetraacetic acid and diethylenetriamine pentaacetic acid bisamides, were synthesized as potential "smart" magnetic resonance imaging contrast agent ...
Ru-based metallostars Na4{Ru[Ln2bpy-DTTA2(H2O)4]3} (Ln = Y, Gd, and Eu) have been self-assembled in aqueous solution and their relaxivity and optical properties unravelled. The ynthesis and the purification of the new, highly stable heptametallic entities ...
