Publication
Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD
Publications associées (33)
Long-Term Depression at Parallel Fiber to Golgi Cell Synapses
Robberechts Q, Wijnants M, Giugliano M, De Schutter E. Longterm depression at parallel fiber to Golgi cell synapses. J Neurophysiol 104: 3413-3423, 2010. First published September 22, 2010; doi:10.1152/jn.00030.2010. Golgi cells (GoCs) are the primary inhi ...
2010Anthrax toxin triggers the activation of src-like kinases to mediate its own uptake
Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Béatrice Kunz
AB-type toxins, like other bacterial toxins, are notably opportunistic molecules. They rely on target cell receptors to reach the appropriate location within the target cell where translocation of their enzymatic subunits occurs. The anthrax toxin, however ...
National Academy of Sciences2010Investigation of novel calcium-related events as suspected contributors to neurodegeneration
Calcium regulates neuronal signaling and viability through a vast range of cellular and molecular mechanisms. However, many details of these mechanisms still remain to be elucidated. It is believed that calcium-related pathways may comprise promising thera ...
EPFL2009Endosomal Trafficking Of Ampa-Type Glutamate Receptors
Many different forms of synaptic plasticity have been shown to ultimately modulate the number of AMPA-type glutamate receptors at the synapse. This trafficking involves lateral movements between synaptic and extrasynaptic sites at the neuron surface, as we ...
2009Elevated NMDA receptor levels and enhanced postsynaptic long-term potentiation induced by prenatal exposure to valproic acid
Valproic acid (VPA) is a powerful teratogen causing birth defects in humans, including autism spectrum disorder (ASD), if exposure occurs during the first trimester of embryogenesis. Learning and memory alterations are common symptoms of ASD, but underlyin ...
2007Structure and dynamics of the neocortical microcircuit connectivity
The neocortex is the most computationally advanced portion of the brain. It is currently assumed to be composed of a large number of "cortical columns" – intricate arrangements of cortical neurons approximately 300-500 µm in diameter and 2-5 mm in height i ...
EPFL2007Spontaneous and evoked synaptic rewiring in the neonatal neocortex
Henry Markram, Jean-Vincent Le Bé
The local microcircuitry of the neocortex is structurally a tabula rasa, with the axon of each pyramidal neuron having numerous submicrometer appositions with the dendrites of all neighboring pyramidal neurons, but is functionally highly selective, with sy ...
2006Membrane trafficking in neurons regulated by new syntaxin 13-interacting proteins
Recently, it has been shown that correct trafficking of neuronal plasma membrane receptors along the endosomal pathway is directly implicated in molecular mechanisms underlying synaptic plasticity and is fundamental for proper neuronal communication. To un ...
EPFL2004Structural basis and biophysical properties of synaptic plasticity studied by atomic force microscopy
In this thesis, we studied two systems important for synaptic plasticity, one presynaptic and another postsynaptic. The protein complex composed of VAMP 2, SNAP-25 and syntaxin 1 (SNARE complex) is essential for docking and fusion of neurotransmitter-fille ...
EPFL2004Functionally independent columns of rat somatosensory barrel cortex revealed with voltage-sensitive dye imaging
Whisker movement is somatotopically represented in rodent neocortex by electrical activity in clearly defined barrels, which can be visualized in living brain slices. The functional architecture of this part of the cortex can thus be mapped in vitro with r ...
2001