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Chromosome dynamics in the yeast interphase nucleus

Publications associées (49)

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The double life of UPF1 in RNA and DNA stability pathways

Joachim Lingner

The DNA and RNA helicase UPF1 is well known for its central role in Nonsense Mediated RNA Decay (NMD), which promotes degradation of mRNAs containing premature stop codons. However, we have recently demonstrated that human UPF1 is also essential for DNA re ...

2006

Formation of aminosilane-oxide interphases

Véronique Michaud, Yves Leterrier, Gabrielle Pax

The aim of this work is to understand the interactions and interphase formation mechanisms between a liquid aminosilane oligomer (γ -APS) and glass, steel or gold surfaces as a function of the pH of the liquid aminosilane. When basic liquid γ -APS (pH 11.4 ...

2006

Sir-mediated repression can occur independently of chromosomal and subnuclear contexts

Thierry Laroche

Epigenetic mechanisms silence the HM mating-type loci in budding yeast. These loci are tightly linked to telomeres, which are also repressed and held together in clusters at the nuclear periphery, much like mammalian heterochromatin. Yeast telomere anchori ...

2004

PPARgamma controls cell proliferation and apoptosis in an RB-dependent manner

Johan Auwerx

The nuclear receptor PPARgamma is implicated in the control of cell proliferation and apoptosis. However, the molecular mechanisms by which it controls these processes remain largely elusive. We show here that PPARgamma activation in the presence of the re ...

2003

The positioning and dynamics of origins of replication in the budding yeast nucleus

Thierry Laroche

We have analyzed the subnuclear position of early- and late-firing origins of DNA replication in intact yeast cells using fluorescence in situ hybridization and green fluorescent protein (GFP)-tagged chromosomal domains. In both cases, origin position was ...

2001

The dynamics of yeast telomeres and silencing proteins through the cell cycle

Thierry Laroche

Genes integrated near the telomeres of budding yeast have a variegated pattern of gene repression that is mediated by the silent information regulatory proteins Sir2p, Sir3p, and Sir4p. Immunolocalization and fluorescence in situ hybridization (FISH) revea ...

2000

Identification of high affinity Tbf1p-binding sites within the budding yeast genome

Thierry Laroche

The yeast TBF1 gene is essential for mitotic growth and encodes a protein that binds the human telomere repeats in vitro, although its cellular function is unknown. The sequence of the DNA-binding domain of Tbf1p is more closely related to that of the huma ...

Oxford University Press2000

Mutation of yeast Ku genes disrupts the subnuclear organization of telomeres

Thierry Laroche

The mammalian Ku70 and Ku86 proteins form a heterodimer that binds to the ends of double-stranded DNA in vitro and is required for repair of radiation-induced strand breaks and V(D)J recombination [1,2]. Deletion of the Saccharomyces cerevisiae genes HDF1 ...

1998

Nuclear organization and silencing: trafficking of Sir proteins

Thierry Laroche

In budding yeast genes integrated near telomeres succumb to a variegated pattern of gene repression that requires the silent information regulatory proteins Sir2p, Sir3p and Sir4p, which form a nucleosome-binding complex. Immunolocalization shows that the ...

1998

Ste12 and Mcm1 regulate cell cycle-dependent transcription of FAR1.

John McKinney

The transcripts of many genes involved in Saccharomyces cerevisiae mating were found to fluctuate during the cell cycle. In the absence of a functional Ste12 transcription factor, both the levels and the cell cycle pattern of expression of these genes were ...

1996