Publications associées à The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Deregulated energy homeostasis represents a hallmark of aging and results from complex gene-by-environment interactions. Here, we discovered that reducing the expression of the gene ech-6 encoding enoyl-CoA hydratase remitted fat diet-induced deleterious e ...

NATURE PORTFOLIO2022

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Johan Auwerx, Kristina Schoonjans

Sirtuin 3 (SIRT3) is a protein deacetylase regulating beta-cell function through inhibiting oxidative stress in obese and diabetic mice, but the detailed mechanism and potential effect of beta-cell-specific SIRT3 on metabolic homeostasis, and its potential ...

AMER DIABETES ASSOC2021

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

Johan Auwerx, Richardus Houtkooper

Background: Nicotinamide riboside (NR) is an NAD(+) precursor that boosts cellular NAD(+) concentrations. Preclinical studies have shown profound metabolic health effects after NR supplementation. Objectives: We aimed to investigate the effects of 6 wk NR ...

OXFORD UNIV PRESS2020

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Johan Auwerx, Dina Hofer

N-acetylaspartate (NAA) is synthesized by aspartate N-acetyltransferase (gene: Nat8l) from acetyl-coenzyme A and aspartate. In the brain, NAA is considered an important energy metabolite for lipid synthesis. However, the role of NAA in peripheral tissues r ...

FEDERATION AMER SOC EXP BIOL2019

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Carlos Canto Alvarez, Sofia Moco, Joanna Ratajczak, Miriam Valera Alberni

Supplementation with the NAD(+) precursor nicotinamide riboside (NR) ameliorates and prevents a broad array of metabolic and aging disorders in mice. However, little is known about the physiological role of endogenous NR metabolism. We have previously show ...

2019

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Catherine Dehollain, Maria-Alexandra Paun, Jean-Baptiste Robert Orhan

A fully parameterized three-dimensional model with specific dimensions has been developed in ANSYS for an insulin injection pen used by diabetic persons. The insulin injection pen has a smart pen cap which hosts four electrodes used for the smart pen cap e ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2019

Modeling and performance investigation of insulin injection pen for diabetic persons

Catherine Dehollain, Maria-Alexandra Paun

This paper is focused on modeling and performance investigation of insulin injection pens used by diabetic persons. A smart pen cap with two electrodes is used as a capacitive sensor for insulin dose detection and is presented in details. To faithfully ana ...

IEEE2019

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Johan Auwerx, Dongryeol Ryu

Reduced mitochondria! electron transport chain activity promotes longevity and improves energy homeostasis via cell-autonomous and non-autonomous factors in multiple model systems. This mitohormetic effect is thought to involve the mitochondrial unfolded p ...

Rockefeller Univ Press2017

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The Pro12Ala PPARgamma2 variant determines metabolism at the gene-environment interface

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

Modeling and performance investigation of insulin injection pen for diabetic persons

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

Graph Chatbot

Chattez avec Graph Search

Reduced ech-6 expression attenuates fat-induced lifespan shortening in C. elegans

Pancreatic Sirtuin 3 Deficiency Promotes Hepatic Steatosis by Enhancing 5-Hydroxytryptamine Synthesis in Mice With Diet-Induced Obesity

Endogenous nicotinamide riboside metabolism protects against diet-induced liver damage

Three-Dimensional Model and Evaluation of an Insulin Injection Pen for Precise Dose Capacitive Measurement

The ULK1/2 and AMPK Inhibitor SBI-0206965 Blocks AICAR and Insulin-Stimulated Glucose Transport

Modeling and performance investigation of insulin injection pen for diabetic persons

Growth differentiation factor 15 is a myomitokine governing systemic energy homeostasis

N-acetylaspartate availability is essential for juvenile survival on fat-free diet and determines metabolic health

Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans

AMP-activated Protein Kinase (AMPK): New molecular insights and novel downstream targets