Publications associées à Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

White adipose tissue distribution and amount are associated with increased white matter connectivity

Jean-Philippe Thiran, Gabriel Girard, Elda Fischi Gomez, Philipp Johannes Koch, Liana Okudzhava

Obesity represents a significant public health concern and is linked to various comorbidities and cognitive impairments. Previous research indicates that elevated body mass index (BMI) is associated with structural changes in white matter (WM). However, a ...

Hoboken2024

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

Johan Auwerx

MicroRNAs (miRNAs) have been implicated in oxidative metabolism and brown/beige adipocyte identity. Here, we tested whether widespread changes in miRNA expression promoted by treatment with the small-molecule enoxacin cause browning and prevent obesity. En ...

AMER ASSOC ADVANCEMENT SCIENCE2020

NTCP deficiency in mice protects against obesity and hepatosteatosis

Kristina Schoonjans

Bile acids play a major role in the regulation of lipid and energy metabolism. Here we propose the hepatic bile acid uptake transporter Na+ taurocholate cotransporting polypeptide (NTCP) as a target to prolong postprandial bile acid elevations in plasma. R ...

AMER SOC CLINICAL INVESTIGATION INC2019

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Lilia Noriega Lopez, Laura Alejandra Velazquez Villegas

White adipose tissue (WAT) can differentiate into beige adipose tissue by the browning process. Some polyphenols, including isoflavones, particularly genistein, are suggested to increase the expression of browning markers. There is evidence that consumptio ...

ELSEVIER SCIENCE INC2019

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

Kristina Schoonjans

A large number of glucagon-like-peptide-1(GLP-1)- and peptide-YY (PYY)-producing L cells are located in the colon, but little is known about their contribution to whole body metabolism. Since bile acids (BAs) increase GLP-1 and PYY release, and since BAs s ...

AMER PHYSIOLOGICAL SOC2019

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Kristina Schoonjans

beta-Klotho (encoded by Klb) is the obligate coreceptor mediating FGF21 and FGF15/19 signaling. Klb(-/-)mice are refractory to beneficial action of pharmacological FGF21 treatment including stimulation of glucose utilization and thermogenesis. Here, we inv ...

Amer Soc Clinical Investigation Inc2017

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Kristina Schoonjans, Alessia Perino

The systemic expression of the bile acid (BA) sensor farnesoid X receptor (FXR) has led to promising new therapies targeting cholesterol metabolism, triglyceride production, hepatic steatosis and biliary cholestasis. In contrast to systemic therapy, bile a ...

Nature Publishing Group2015

Blood Plasma Lipidomic Signature of Epicardial Fat in Healthy Obese Women

Martin Kussmann, Sebastiano Collino

ObjectivesA lipidomic approach was employed in a clinically well-defined cohort of healthy obese women to explore blood lipidome phenotype ascribed to body fat deposition, with emphasis on epicardial adipose tissue (EAT). MethodsThe present investigation d ...

Wiley-Blackwell2015

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

Kristina Schoonjans, Alessia Perino, Yasmine Sebti

Bile acids are signalling molecules, which activate the transmembrane receptor TGR5 and the nuclear receptor FXR. BA sequestrants (BAS) complex bile acids in the intestinal lumen and decrease intestinal FXR activity. The BAS-BA complex also induces glucago ...

Nature Publishing Group2015

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Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation

White adipose tissue distribution and amount are associated with increased white matter connectivity

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

NTCP deficiency in mice protects against obesity and hepatosteatosis

The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Blood Plasma Lipidomic Signature of Epicardial Fat in Healthy Obese Women

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

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Chattez avec Graph Search

Enoxacin induces oxidative metabolism and mitigates obesity by regulating adipose tissue miRNA expression

NTCP deficiency in mice protects against obesity and hepatosteatosis

Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance

Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells

White adipose tissue distribution and amount are associated with increased white matter connectivity

Blood Plasma Lipidomic Signature of Epicardial Fat in Healthy Obese Women

Bile acids drive colonic secretion of glucagon-like-peptide 1 and peptide-YY in rodents

beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue

The role of the transcriptional regulator BCL6 in adipose tissue development and remodeling

Genistein increases the thermogenic program of subcutaneous WAT and increases energy expenditure in mice