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Sensory experience in early life shapes the mammalian brain. An impairment in the activity-dependent refinement of functional connections within developing visual cortex was identified here in a mouse model. Gene-targeted disruption of one isoform of gluta ...
American Association for the Advancement of Science1998
We propose an alternative paradigm for processing time-varying visual inputs, in particular for tasks involving temporal and spatial integration, which is inspired by hypotheses about the computational role of cortical microcircuits. Since detailed knowled ...
A challenge for neurobiology is to integrate information across many levels of research, ranging from behaviour and neuronal networks to cells and molecules. The rodent whisker signalling pathway to the primary somatosensory neocortex with its remarkable s ...
The structure of cross-correlations between subthreshold potentials of neocortical neurons was recently examined. Characteristic features included broad widths and significant peak advances. It was suggested that dynamic synapses shape these cross-correlat ...
Whole-cell patch-clamp recordings followed by histochemical staining and single-cell RT-PCR were obtained from 180 Martinotti interneurones located in layers II to VI of the somatosensory cortex of Wistar rats (P13-P16) in order to examine their anatomical ...
The human primary auditory cortex (AI) is surrounded by several other auditory areas, which can be identified by cyto-, myelo- and chemoarchitectonic criteria. We report here on the pattern of calcium-binding protein immunoreactivity within these areas. Th ...
Perception of a visual target and the responses of cortical neurons can be strongly influenced by a context surrounding the target(1-27). This observation relates to the fundamental issue of how cortical neurons code objects of the external world. In high- ...
Multipotent precursors able to generate neurons, astrocytes, and oligodendrocytes have previously been isolated from human brain embryos and recently from neurogenic regions of the adult human brains. The isolation of multipotent neural precursors from adu ...
The mechanisms responsible for the local increase in brain glucose utilization during functional activation remain unknown. Recent in vitro studies have identified a new signaling pathway involving an activation of glial glutamate transporters and enhancem ...
We analyse a model for the development of orientation-selective receptive fields of simple cells in a locally connected network of cortical neurons. The Hebbian learning rule that underlies the development is described by a linear differential equation. Th ...
