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Suv-HMTases and their impact on tumor formation and telomere regulation

Publications associées (49)

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The Developmental Control of Transposable Elements and the Evolution of Higher Species

Didier Trono, Marc Samuel Friedli

Transposable elements (TEs) account for at least 50% of the human genome. They constitute essential motors of evolution through their ability to modify genomic architecture, mutate genes and regulate gene expression. Accordingly, TEs are subject to tight e ...

Annual Reviews2015

Microfluidic engineering of artificial stem cell niches

Simone Allazetta

Stem cells play a key role in a wide range of biological processes, in large part due to their ability to self-renew or differentiate into specialized cell types in response to various biological cues. In vivo, stem cells reside in a complex microenvironme ...

EPFL2015

The long-term risk of malignancy associated with stem cell therapies is a significant concern in the clinical application of this exciting technology. We report a cancer-selective strategy to enhance the safety of stem cell therapies. Briefly, using a cell ...

Elsevier2014

Myogenic potential of canine craniofacial satellite cells

Marco Cassano

The skeletal fibers have different embryological origin; the extraocular and jaw-closer muscles develop from prechordal mesoderm while the limb and trunk muscles from somites. These different origins characterize also the adult muscle stem cells, known as ...

Frontiers Research Foundation2014

The Mesenchymal Stem Cell (MSC) is a self-renewing multipotent progenitor originally found in the bone marrow. It has drawn strong interest from translational research because of the multipotency of MSCs, their immunosuppression, their intrinsic homing and ...

EPFL2014

Interplay of TRIM28 and DNA methylation in controlling human endogenous retroelements

Didier Trono, Priscilla Turelli, Julien Léonard Duc, Charlène Mireille Raymonde Raclot, Adamantia Kapopoulou, Flavia Marzetta

Reverse transcription-derived sequences account for at least half of the human genome. Although these retroelements are formidable motors of evolution, they can occasionally cause disease, and accordingly are inactivated during early embryogenesis through ...

Cold Spring Harbor Lab Press, Publications Dept2014

Comparison between reduced basis and stochastic collocation methods for elliptic problems

Alfio Quarteroni, Gianluigi Rozza, Peng Chen

The stochastic collocation method has recently been applied to stochastic problems that can be transformed into parametric systems. Meanwhile, the reduced basis method, primarily developed for solving parametric systems, has been recently used to deal with ...

Springer Verlag2014

De novo DNA methylation of endogenous retroviruses is shaped by KRAB-ZFPs/KAP1 and ESET

Didier Trono, Sonia Verp, Marc Samuel Friedli, Sandra Eloise Kjeldsen, Helen Mary Rowe

Endogenous retroviruses (ERVs) undergo de novo DNA methylation during the first few days of mammalian embryogenesis, although the factors that control the targeting of this process are largely unknown. We asked whether KAP1 (KRAB-associated protein 1) is i ...

Company Of Biologists Ltd2013

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Copy number variants (CNVs) influence the expression of genes that map not only within the rearrangement, but also to its flanks. To assess the possible mechanism(s) underlying this "neighboring effect", we compared intrachromosomal interactions and histon ...

Public Library of Science2013

A quantitative telomeric chromatin isolation protocol identifies different telomeric states

Joachim Lingner, Romain Hamelin, Florence Armand, Diego Chiappe, Marc Moniatte, Eric Aeby, Larissa Grolimund

Telomere composition changes during tumourigenesis, aging and in telomere syndromes in a poorly defined manner. Here we develop a quantitative telomeric chromatin isolation protocol (QTIP) for human cells, in which chromatin is cross-linked, immunopurified ...

Nature Publishing Group2013