Investigation of the GK domain of PSD-95 in synaptic strength and structure

2008
Projet étudiant

Résumé

[...] Our findings show that a mutant of PSD-95 that lacks its GK domain clusters along the dendritic shaft and dramatically decreases the spine density without affecting the frequency of miniature excitatory postsynaptic currents (mEPSCs)[... click on "Download fulltext" for full abstract]

Source officielle

https://infoscience.epfl.ch/record/139162?ln=fr

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Investigation of the GK domain of PSD-95 in synaptic strength and structure

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Long-term plasticity induces sparse and specific synaptic changes in a biophysically detailed cortical model

Principles of Network Plasticity in Neocortical Microcircuits

Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit